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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLE3 All Species: 24.24
Human Site: T83 Identified Species: 44.44
UniProt: Q9NRF9 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NRF9 NP_059139.3 147 16860 T83 M E F Q R F V T P L K E A L E
Chimpanzee Pan troglodytes XP_001153197 176 19753 T112 M E F Q R F V T P L K E A L E
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_855374 283 30359 T219 M E F Q R F V T P L K E A L E
Cat Felis silvestris
Mouse Mus musculus Q9JKP7 145 16611 T83 M E F Q R F I T P L K E A L E
Rat Rattus norvegicus Q642A5 145 16656 T83 M E F Q R F V T P L K E A L E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001020525 143 16341 A83 M E F Q R F I A P L K E S L E
Frog Xenopus laevis NP_001084468 147 16813 T83 M E F Q R F L T P L K E S L E
Zebra Danio Brachydanio rerio NP_957095 148 16781 Q83 M E F E R F L Q P L R E A L E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_476646 128 13825 S80 L T E L D F E S F V P S L T Q
Honey Bee Apis mellifera XP_001122640 129 14452 D83 I E F D E F V D P L Q E S L E
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785187 199 21870 E83 M E F S E F T E P L R A N L E
Poplar Tree Populus trichocarpa XP_002312821 145 15950 G92 I E F P E F V G P L K V S L S
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FGJ3 190 20511 E105 L G F E D Y V E P L K V Y L Q
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 83.5 N.A. 51.2 N.A. 91.1 95.9 N.A. N.A. 88.4 84.3 75 N.A. 42.8 52.3 N.A. 48.7
Protein Similarity: 100 83.5 N.A. 51.5 N.A. 97.9 97.9 N.A. N.A. 94.5 97.2 89.1 N.A. 57.1 68.7 N.A. 62.3
P-Site Identity: 100 100 N.A. 100 N.A. 93.3 100 N.A. N.A. 80 86.6 73.3 N.A. 6.6 60 N.A. 53.3
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. N.A. 93.3 100 93.3 N.A. 33.3 80 N.A. 60
Percent
Protein Identity: 32.6 N.A. N.A. 21.5 N.A. N.A.
Protein Similarity: 55.1 N.A. N.A. 40.5 N.A. N.A.
P-Site Identity: 53.3 N.A. N.A. 40 N.A. N.A.
P-Site Similarity: 66.6 N.A. N.A. 66.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 8 0 0 0 8 47 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 8 16 0 0 8 0 0 0 0 0 0 0 % D
% Glu: 0 85 8 16 24 0 8 16 0 0 0 70 0 0 77 % E
% Phe: 0 0 93 0 0 93 0 0 8 0 0 0 0 0 0 % F
% Gly: 0 8 0 0 0 0 0 8 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 16 0 0 0 0 0 16 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 70 0 0 0 0 % K
% Leu: 16 0 0 8 0 0 16 0 0 93 0 0 8 93 0 % L
% Met: 70 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % N
% Pro: 0 0 0 8 0 0 0 0 93 0 8 0 0 0 0 % P
% Gln: 0 0 0 54 0 0 0 8 0 0 8 0 0 0 16 % Q
% Arg: 0 0 0 0 62 0 0 0 0 0 16 0 0 0 0 % R
% Ser: 0 0 0 8 0 0 0 8 0 0 0 8 31 0 8 % S
% Thr: 0 8 0 0 0 0 8 47 0 0 0 0 0 8 0 % T
% Val: 0 0 0 0 0 0 54 0 0 8 0 16 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 8 0 0 0 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _