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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMYD2
All Species:
31.82
Human Site:
Y245
Identified Species:
53.85
UniProt:
Q9NRG4
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NRG4
NP_064582.2
433
49688
Y245
T
S
Y
I
D
L
L
Y
P
T
E
D
R
N
D
Chimpanzee
Pan troglodytes
XP_514316
454
52196
M270
I
C
Y
L
D
M
L
M
T
S
E
E
R
R
K
Rhesus Macaque
Macaca mulatta
XP_001106482
433
49665
Y245
T
S
Y
I
D
L
L
Y
P
T
E
D
R
N
D
Dog
Lupus familis
XP_537149
432
49720
Y244
T
S
Y
I
D
L
L
Y
P
T
E
D
R
N
D
Cat
Felis silvestris
Mouse
Mus musculus
Q8R5A0
433
49548
Y245
T
S
Y
I
D
L
L
Y
P
T
E
D
R
N
D
Rat
Rattus norvegicus
Q7M6Z3
433
49630
Y245
T
S
Y
I
D
L
L
Y
P
T
E
D
R
N
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510161
439
49949
Y251
T
S
Y
I
D
L
L
Y
P
T
E
D
R
N
D
Chicken
Gallus gallus
XP_419420
436
49919
Y248
T
S
Y
I
D
L
L
Y
P
T
E
D
R
N
D
Frog
Xenopus laevis
NP_001085986
430
49101
Y243
T
S
Y
I
D
L
L
Y
P
T
E
D
R
N
D
Zebra Danio
Brachydanio rerio
NP_001013568
435
50045
P246
S
Y
I
D
L
L
Y
P
T
E
D
R
I
E
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O46040
462
52138
I289
I
T
T
T
Y
T
K
I
L
W
G
N
L
T
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09415
429
48527
C237
K
Y
K
F
L
C
Q
C
D
G
C
L
D
E
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001131420
482
54569
V278
T
C
T
C
P
R
C
V
K
G
F
D
E
D
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q7XJS0
480
54809
P280
R
C
S
N
F
G
K
P
H
D
I
E
E
S
A
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
32.8
99
92.6
N.A.
93.3
93.5
N.A.
80.6
85.5
78.7
75.4
N.A.
20.5
N.A.
22.6
N.A.
Protein Similarity:
100
53.7
99
94.2
N.A.
96.5
97
N.A.
85.8
94
88.2
87.3
N.A.
35
N.A.
42.7
N.A.
P-Site Identity:
100
33.3
100
100
N.A.
100
100
N.A.
100
100
100
6.6
N.A.
0
N.A.
6.6
N.A.
P-Site Similarity:
100
60
100
100
N.A.
100
100
N.A.
100
100
100
20
N.A.
13.3
N.A.
6.6
N.A.
Percent
Protein Identity:
N.A.
29.8
N.A.
25.8
N.A.
N.A.
Protein Similarity:
N.A.
46.4
N.A.
45.8
N.A.
N.A.
P-Site Identity:
N.A.
13.3
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
20
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
15
% A
% Cys:
0
22
0
8
0
8
8
8
0
0
8
0
0
0
0
% C
% Asp:
0
0
0
8
65
0
0
0
8
8
8
65
8
8
65
% D
% Glu:
0
0
0
0
0
0
0
0
0
8
65
15
15
15
0
% E
% Phe:
0
0
0
8
8
0
0
0
0
0
8
0
0
0
0
% F
% Gly:
0
0
0
0
0
8
0
0
0
15
8
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
15
0
8
58
0
0
0
8
0
0
8
0
8
0
0
% I
% Lys:
8
0
8
0
0
0
15
0
8
0
0
0
0
0
8
% K
% Leu:
0
0
0
8
15
65
65
0
8
0
0
8
8
0
0
% L
% Met:
0
0
0
0
0
8
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
0
0
0
0
0
0
0
8
0
58
0
% N
% Pro:
0
0
0
0
8
0
0
15
58
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% Q
% Arg:
8
0
0
0
0
8
0
0
0
0
0
8
65
8
15
% R
% Ser:
8
58
8
0
0
0
0
0
0
8
0
0
0
8
0
% S
% Thr:
65
8
15
8
0
8
0
0
15
58
0
0
0
8
0
% T
% Val:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% W
% Tyr:
0
15
65
0
8
0
8
58
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _