KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMYD2
All Species:
38.79
Human Site:
Y374
Identified Species:
65.64
UniProt:
Q9NRG4
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NRG4
NP_064582.2
433
49688
Y374
I
K
P
Y
S
K
H
Y
P
L
Y
S
L
N
V
Chimpanzee
Pan troglodytes
XP_514316
454
52196
V399
H
P
V
R
G
V
Q
V
M
K
V
G
K
L
Q
Rhesus Macaque
Macaca mulatta
XP_001106482
433
49665
Y374
I
K
P
Y
S
K
H
Y
P
L
Y
S
L
N
V
Dog
Lupus familis
XP_537149
432
49720
Y373
I
K
P
Y
S
K
H
Y
P
L
Y
S
L
N
V
Cat
Felis silvestris
Mouse
Mus musculus
Q8R5A0
433
49548
Y374
I
K
P
Y
S
K
H
Y
P
V
Y
S
L
N
V
Rat
Rattus norvegicus
Q7M6Z3
433
49630
Y374
I
K
P
Y
S
K
H
Y
P
V
Y
S
L
N
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510161
439
49949
Y380
I
K
P
Y
S
K
H
Y
P
L
Y
S
L
N
V
Chicken
Gallus gallus
XP_419420
436
49919
Y377
I
R
P
Y
S
K
H
Y
P
S
Y
S
L
N
V
Frog
Xenopus laevis
NP_001085986
430
49101
Y372
I
K
P
Y
S
K
H
Y
P
A
Y
S
L
N
V
Zebra Danio
Brachydanio rerio
NP_001013568
435
50045
Y375
I
H
P
Y
S
V
H
Y
P
P
Y
S
L
N
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O46040
462
52138
R418
N
V
I
W
R
M
T
R
F
D
H
E
E
Y
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09415
429
48527
Q366
L
S
I
M
L
V
Y
Q
N
T
T
D
P
A
I
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001131420
482
54569
Y407
I
P
V
Y
E
R
V
Y
P
P
F
H
P
M
I
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q7XJS0
480
54809
Y409
V
P
V
Y
Q
R
V
Y
P
A
T
H
P
L
I
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
32.8
99
92.6
N.A.
93.3
93.5
N.A.
80.6
85.5
78.7
75.4
N.A.
20.5
N.A.
22.6
N.A.
Protein Similarity:
100
53.7
99
94.2
N.A.
96.5
97
N.A.
85.8
94
88.2
87.3
N.A.
35
N.A.
42.7
N.A.
P-Site Identity:
100
0
100
100
N.A.
93.3
93.3
N.A.
100
86.6
93.3
80
N.A.
0
N.A.
0
N.A.
P-Site Similarity:
100
0
100
100
N.A.
100
100
N.A.
100
93.3
93.3
80
N.A.
13.3
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
29.8
N.A.
25.8
N.A.
N.A.
Protein Similarity:
N.A.
46.4
N.A.
45.8
N.A.
N.A.
P-Site Identity:
N.A.
26.6
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
46.6
N.A.
40
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
15
0
0
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
8
0
8
0
0
0
% D
% Glu:
0
0
0
0
8
0
0
0
0
0
0
8
8
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
8
0
8
0
0
0
0
% F
% Gly:
0
0
0
0
8
0
0
0
0
0
0
8
0
0
0
% G
% His:
8
8
0
0
0
0
65
0
0
0
8
15
0
0
0
% H
% Ile:
72
0
15
0
0
0
0
0
0
0
0
0
0
0
22
% I
% Lys:
0
50
0
0
0
58
0
0
0
8
0
0
8
0
0
% K
% Leu:
8
0
0
0
8
0
0
0
0
29
0
0
65
15
0
% L
% Met:
0
0
0
8
0
8
0
0
8
0
0
0
0
8
0
% M
% Asn:
8
0
0
0
0
0
0
0
8
0
0
0
0
65
0
% N
% Pro:
0
22
65
0
0
0
0
0
79
15
0
0
22
0
0
% P
% Gln:
0
0
0
0
8
0
8
8
0
0
0
0
0
0
8
% Q
% Arg:
0
8
0
8
8
15
0
8
0
0
0
0
0
0
0
% R
% Ser:
0
8
0
0
65
0
0
0
0
8
0
65
0
0
0
% S
% Thr:
0
0
0
0
0
0
8
0
0
8
15
0
0
0
8
% T
% Val:
8
8
22
0
0
22
15
8
0
15
8
0
0
0
65
% V
% Trp:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
79
0
0
8
79
0
0
65
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _