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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PAPOLB All Species: 20.3
Human Site: S592 Identified Species: 37.22
UniProt: Q9NRJ5 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NRJ5 NP_064529.4 636 71681 S592 S G V A L N E S I P H A V S Q
Chimpanzee Pan troglodytes XP_515496 714 80108 G581 L S V P P A Q G L S I P V I G
Rhesus Macaque Macaca mulatta XP_001101831 825 90125 A653 T D L S D I P A L P A N P I P
Dog Lupus familis XP_537551 812 90509 S667 S G G T S S E S I P Q T A T Q
Cat Felis silvestris
Mouse Mus musculus Q9WVP6 641 72180 S592 S G I A L S E S I P Q I P S Q
Rat Rattus norvegicus NP_001012020 642 72321 S593 S G I A L S E S I A Q I P S Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511509 736 82218 S591 S G G S S S E S I P Q T A T Q
Chicken Gallus gallus XP_421352 737 82879 S593 S G G S S N E S I P Q T A T Q
Frog Xenopus laevis P51004 715 80169 S574 L G G S L N E S I P E S A T H
Zebra Danio Brachydanio rerio NP_991321 723 80246 K590 S S S N A S G K G A A P P Q S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_393202 615 69546 V572 H G E D G S L V V Q S C G E D
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_780989 670 74465 T611 G G E P V S L T S D C N E N G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P29468 568 64534 N525 P D E V F D E N E K R P S K K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 56.2 40.8 67.7 N.A. 85 85.1 N.A. 73.7 72.8 67.8 64.3 N.A. N.A. 53.6 N.A. 50
Protein Similarity: 100 70.3 52.1 71.5 N.A. 89.6 90 N.A. 77.9 78.5 75.3 73.5 N.A. N.A. 68.8 N.A. 64.4
P-Site Identity: 100 13.3 6.6 46.6 N.A. 66.6 60 N.A. 46.6 53.3 46.6 6.6 N.A. N.A. 6.6 N.A. 6.6
P-Site Similarity: 100 26.6 40 60 N.A. 80 73.3 N.A. 66.6 66.6 66.6 13.3 N.A. N.A. 20 N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 33.8 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 54.2 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 24 8 8 0 8 0 16 16 8 31 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 8 8 0 0 0 % C
% Asp: 0 16 0 8 8 8 0 0 0 8 0 0 0 0 8 % D
% Glu: 0 0 24 0 0 0 62 0 8 0 8 0 8 8 0 % E
% Phe: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 70 31 0 8 0 8 8 8 0 0 0 8 0 16 % G
% His: 8 0 0 0 0 0 0 0 0 0 8 0 0 0 8 % H
% Ile: 0 0 16 0 0 8 0 0 54 0 8 16 0 16 0 % I
% Lys: 0 0 0 0 0 0 0 8 0 8 0 0 0 8 8 % K
% Leu: 16 0 8 0 31 0 16 0 16 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 8 0 24 0 8 0 0 0 16 0 8 0 % N
% Pro: 8 0 0 16 8 0 8 0 0 54 0 24 31 0 8 % P
% Gln: 0 0 0 0 0 0 8 0 0 8 39 0 0 8 47 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % R
% Ser: 54 16 8 31 24 54 0 54 8 8 8 8 8 24 8 % S
% Thr: 8 0 0 8 0 0 0 8 0 0 0 24 0 31 0 % T
% Val: 0 0 16 8 8 0 0 8 8 0 0 0 16 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _