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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: INPP5E All Species: 8.79
Human Site: S143 Identified Species: 17.58
UniProt: Q9NRR6 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NRR6 NP_063945.2 644 70205 S143 S L Q E I P K S R G V L S S E
Chimpanzee Pan troglodytes A0FI79 644 70203 S143 S L Q E I P K S R G V L S S E
Rhesus Macaque Macaca mulatta XP_001095203 644 70159 S143 S L Q E I P K S R G V L G S E
Dog Lupus familis XP_849208 665 73376 G164 P R P P G P P G S P P C L S T
Cat Felis silvestris
Mouse Mus musculus Q9JII1 647 71896 K146 T S L Q E I P K S R R A T G S
Rat Rattus norvegicus Q9WVR1 647 72220 K146 T S L Q E I P K P R R P Q A A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521280 342 39128
Chicken Gallus gallus XP_415418 659 73992 E158 H S S P D A S E E S P V G K S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_648566 747 82572 F234 P V A S K T F F A H C S P A A
Honey Bee Apis mellifera XP_392662 684 76969 R174 Y F F L E M E R Q F Y N P F D
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_796959 989 110275 V431 I E L P N R T V L G D E D E I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FUR2 646 73561 E172 R G P I P K W E S I I R R T L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 97.8 71.8 N.A. 76.6 75.7 N.A. 43.9 61.1 N.A. N.A. N.A. 32.9 32.1 N.A. 31.3
Protein Similarity: 100 99.5 98.4 79.6 N.A. 83.6 83 N.A. 49.6 71.6 N.A. N.A. N.A. 46.4 48.9 N.A. 43.3
P-Site Identity: 100 100 93.3 13.3 N.A. 0 0 N.A. 0 0 N.A. N.A. N.A. 0 0 N.A. 6.6
P-Site Similarity: 100 100 93.3 13.3 N.A. 20 20 N.A. 0 6.6 N.A. N.A. N.A. 13.3 20 N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. 20.9 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 38.7 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 9 0 0 9 0 0 9 0 0 9 0 17 17 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 9 9 0 0 0 % C
% Asp: 0 0 0 0 9 0 0 0 0 0 9 0 9 0 9 % D
% Glu: 0 9 0 25 25 0 9 17 9 0 0 9 0 9 25 % E
% Phe: 0 9 9 0 0 0 9 9 0 9 0 0 0 9 0 % F
% Gly: 0 9 0 0 9 0 0 9 0 34 0 0 17 9 0 % G
% His: 9 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % H
% Ile: 9 0 0 9 25 17 0 0 0 9 9 0 0 0 9 % I
% Lys: 0 0 0 0 9 9 25 17 0 0 0 0 0 9 0 % K
% Leu: 0 25 25 9 0 0 0 0 9 0 0 25 9 0 9 % L
% Met: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 9 0 0 0 0 0 0 9 0 0 0 % N
% Pro: 17 0 17 25 9 34 25 0 9 9 17 9 17 0 0 % P
% Gln: 0 0 25 17 0 0 0 0 9 0 0 0 9 0 0 % Q
% Arg: 9 9 0 0 0 9 0 9 25 17 17 9 9 0 0 % R
% Ser: 25 25 9 9 0 0 9 25 25 9 0 9 17 34 17 % S
% Thr: 17 0 0 0 0 9 9 0 0 0 0 0 9 9 9 % T
% Val: 0 9 0 0 0 0 0 9 0 0 25 9 0 0 0 % V
% Trp: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % W
% Tyr: 9 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _