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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
VPS45
All Species:
28.18
Human Site:
S424
Identified Species:
51.67
UniProt:
Q9NRW7
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NRW7
NP_009190.2
570
65077
S424
E
K
Y
R
K
L
V
S
A
V
V
E
Y
G
G
Chimpanzee
Pan troglodytes
XP_001167625
570
65076
S424
E
K
Y
R
K
L
V
S
A
V
V
E
Y
G
G
Rhesus Macaque
Macaca mulatta
XP_001098282
570
65092
S424
E
K
Y
R
K
L
V
S
A
V
V
E
Y
G
G
Dog
Lupus familis
XP_533042
570
65044
S424
E
K
Y
R
K
L
V
S
A
V
V
E
Y
G
G
Cat
Felis silvestris
Mouse
Mus musculus
P97390
570
65034
S424
E
K
Y
R
K
L
V
S
A
V
V
E
Y
G
G
Rat
Rattus norvegicus
O08700
570
64875
S424
E
K
Y
R
K
L
V
S
A
V
V
E
Y
G
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001026764
377
42830
M234
S
N
S
L
P
G
L
M
A
D
L
K
N
R
G
Frog
Xenopus laevis
NP_001088217
570
65179
S424
D
K
Y
R
R
L
V
S
A
V
V
E
Y
G
G
Zebra Danio
Brachydanio rerio
XP_707890
568
64880
H424
E
R
H
R
K
M
V
H
A
V
V
E
Y
G
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24179
657
74488
G467
K
E
A
L
Q
A
A
G
C
D
L
T
A
L
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_792131
555
63749
R412
L
M
E
M
L
R
R
R
G
V
G
D
K
H
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O49048
569
64924
S423
F
N
K
L
A
S
R
S
P
K
Y
K
P
G
L
Baker's Yeast
Sacchar. cerevisiae
P38932
577
66999
V431
Q
Q
L
P
P
E
D
V
N
F
F
H
K
F
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.4
98.9
N.A.
97
97.1
N.A.
N.A.
60.8
86.3
82.1
N.A.
23.8
N.A.
N.A.
66.6
Protein Similarity:
100
100
99.8
99.8
N.A.
99.4
99.3
N.A.
N.A.
63.8
93.5
91.7
N.A.
44.7
N.A.
N.A.
80.7
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
13.3
86.6
73.3
N.A.
0
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
33.3
100
93.3
N.A.
26.6
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
45.6
37
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
67.1
60.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
8
8
8
0
70
0
0
0
8
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
0
8
0
0
16
0
8
0
0
0
% D
% Glu:
54
8
8
0
0
8
0
0
0
0
0
62
0
0
0
% E
% Phe:
8
0
0
0
0
0
0
0
0
8
8
0
0
8
0
% F
% Gly:
0
0
0
0
0
8
0
8
8
0
8
0
0
70
70
% G
% His:
0
0
8
0
0
0
0
8
0
0
0
8
0
8
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
8
54
8
0
54
0
0
0
0
8
0
16
16
0
8
% K
% Leu:
8
0
8
24
8
54
8
0
0
0
16
0
0
8
8
% L
% Met:
0
8
0
8
0
8
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
16
0
0
0
0
0
0
8
0
0
0
8
0
0
% N
% Pro:
0
0
0
8
16
0
0
0
8
0
0
0
8
0
0
% P
% Gln:
8
8
0
0
8
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
8
0
62
8
8
16
8
0
0
0
0
0
8
8
% R
% Ser:
8
0
8
0
0
8
0
62
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% T
% Val:
0
0
0
0
0
0
62
8
0
70
62
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
54
0
0
0
0
0
0
0
8
0
62
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _