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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
VPS45
All Species:
26.67
Human Site:
S559
Identified Species:
48.89
UniProt:
Q9NRW7
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NRW7
NP_009190.2
570
65077
S559
L
H
S
R
S
K
E
S
S
Q
V
T
S
R
S
Chimpanzee
Pan troglodytes
XP_001167625
570
65076
S559
L
H
S
R
S
K
E
S
S
Q
V
T
S
R
S
Rhesus Macaque
Macaca mulatta
XP_001098282
570
65092
S559
L
H
S
R
S
K
E
S
S
Q
V
T
S
R
S
Dog
Lupus familis
XP_533042
570
65044
S559
L
H
S
R
S
K
E
S
S
Q
V
T
S
R
S
Cat
Felis silvestris
Mouse
Mus musculus
P97390
570
65034
S559
L
H
S
R
S
R
E
S
S
Q
A
T
S
R
S
Rat
Rattus norvegicus
O08700
570
64875
S559
L
H
S
R
S
R
E
S
S
Q
A
T
S
R
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001026764
377
42830
T367
G
G
T
T
I
H
N
T
R
R
K
Q
S
C
A
Frog
Xenopus laevis
NP_001088217
570
65179
G559
F
Q
G
R
S
G
E
G
Y
Q
A
A
V
K
S
Zebra Danio
Brachydanio rerio
XP_707890
568
64880
S558
V
G
S
G
G
D
R
S
Q
I
G
G
R
Q
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24179
657
74488
I626
T
S
N
V
Q
R
R
I
I
Y
G
A
S
T
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_792131
555
63749
E545
N
F
E
S
F
L
E
E
V
S
S
T
G
I
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O49048
569
64924
E557
R
F
L
K
D
L
E
E
A
Q
R
I
S
R
S
Baker's Yeast
Sacchar. cerevisiae
P38932
577
66999
S565
L
G
G
T
S
I
L
S
T
K
E
Y
M
D
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.4
98.9
N.A.
97
97.1
N.A.
N.A.
60.8
86.3
82.1
N.A.
23.8
N.A.
N.A.
66.6
Protein Similarity:
100
100
99.8
99.8
N.A.
99.4
99.3
N.A.
N.A.
63.8
93.5
91.7
N.A.
44.7
N.A.
N.A.
80.7
P-Site Identity:
100
100
100
100
N.A.
86.6
86.6
N.A.
N.A.
6.6
33.3
13.3
N.A.
6.6
N.A.
N.A.
13.3
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
N.A.
33.3
40
26.6
N.A.
20
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
45.6
37
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
67.1
60.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
33.3
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
8
0
24
16
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
0
0
0
0
8
8
0
0
0
0
0
0
0
8
0
% D
% Glu:
0
0
8
0
0
0
70
16
0
0
8
0
0
0
8
% E
% Phe:
8
16
0
0
8
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
24
16
8
8
8
0
8
0
0
16
8
8
0
0
% G
% His:
0
47
0
0
0
8
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
8
8
0
8
8
8
0
8
0
8
0
% I
% Lys:
0
0
0
8
0
31
0
0
0
8
8
0
0
8
0
% K
% Leu:
54
0
8
0
0
16
8
0
0
0
0
0
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
8
% M
% Asn:
8
0
8
0
0
0
8
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
8
0
0
8
0
0
0
8
62
0
8
0
8
0
% Q
% Arg:
8
0
0
54
0
24
16
0
8
8
8
0
8
54
0
% R
% Ser:
0
8
54
8
62
0
0
62
47
8
8
0
70
0
70
% S
% Thr:
8
0
8
16
0
0
0
8
8
0
0
54
0
8
0
% T
% Val:
8
0
0
8
0
0
0
0
8
0
31
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
8
8
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _