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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VPS45 All Species: 26.97
Human Site: Y81 Identified Species: 49.44
UniProt: Q9NRW7 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NRW7 NP_009190.2 570 65077 Y81 P T K E N V D Y I I Q E L R R
Chimpanzee Pan troglodytes XP_001167625 570 65076 Y81 P T K E N V D Y M I Q E L R R
Rhesus Macaque Macaca mulatta XP_001098282 570 65092 Y81 P T K E N V D Y M I Q E L R R
Dog Lupus familis XP_533042 570 65044 Y81 P T K E N V D Y L I Q E L R R
Cat Felis silvestris
Mouse Mus musculus P97390 570 65034 Y81 P T K E N V E Y L I Q E L R R
Rat Rattus norvegicus O08700 570 64875 S81 P T K E N V D S L I Q E L R R
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001026764 377 42830
Frog Xenopus laevis NP_001088217 570 65179 Y81 P T K E N L E Y L I K E L R R
Zebra Danio Brachydanio rerio XP_707890 568 64880 H81 P T K E N V E H L I Q E L R R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24179 657 74488 R90 P T D E N L D R I Q Q D F S S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_792131 555 63749 M81 P K R E N I E M L C N E L R N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O49048 569 64924 K82 P T S D N I Q K L R Y Q L A N
Baker's Yeast Sacchar. cerevisiae P38932 577 66999 H91 P T E E T L Q H L L R E L R N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 99.4 98.9 N.A. 97 97.1 N.A. N.A. 60.8 86.3 82.1 N.A. 23.8 N.A. N.A. 66.6
Protein Similarity: 100 100 99.8 99.8 N.A. 99.4 99.3 N.A. N.A. 63.8 93.5 91.7 N.A. 44.7 N.A. N.A. 80.7
P-Site Identity: 100 93.3 93.3 93.3 N.A. 86.6 86.6 N.A. N.A. 0 73.3 80 N.A. 46.6 N.A. N.A. 40
P-Site Similarity: 100 100 100 100 N.A. 100 93.3 N.A. N.A. 0 100 100 N.A. 60 N.A. N.A. 66.6
Percent
Protein Identity: N.A. N.A. N.A. 45.6 37 N.A.
Protein Similarity: N.A. N.A. N.A. 67.1 60.6 N.A.
P-Site Identity: N.A. N.A. N.A. 26.6 40 N.A.
P-Site Similarity: N.A. N.A. N.A. 53.3 80 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % C
% Asp: 0 0 8 8 0 0 47 0 0 0 0 8 0 0 0 % D
% Glu: 0 0 8 85 0 0 31 0 0 0 0 77 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 16 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 16 0 0 16 62 0 0 0 0 0 % I
% Lys: 0 8 62 0 0 0 0 8 0 0 8 0 0 0 0 % K
% Leu: 0 0 0 0 0 24 0 0 62 8 0 0 85 0 0 % L
% Met: 0 0 0 0 0 0 0 8 16 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 85 0 0 0 0 0 8 0 0 0 24 % N
% Pro: 93 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 16 0 0 8 62 8 0 0 0 % Q
% Arg: 0 0 8 0 0 0 0 8 0 8 8 0 0 77 62 % R
% Ser: 0 0 8 0 0 0 0 8 0 0 0 0 0 8 8 % S
% Thr: 0 85 0 0 8 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 54 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 47 0 0 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _