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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HELLS
All Species:
26.67
Human Site:
S660
Identified Species:
58.67
UniProt:
Q9NRZ9
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NRZ9
NP_060533.2
838
97074
S660
E
R
E
K
N
M
H
S
F
N
T
D
P
E
V
Chimpanzee
Pan troglodytes
XP_001151268
838
97110
S660
E
R
E
K
N
M
H
S
F
N
T
D
P
E
V
Rhesus Macaque
Macaca mulatta
XP_001095698
837
97013
S659
E
R
E
K
N
M
H
S
F
N
M
D
P
E
V
Dog
Lupus familis
XP_543938
837
96810
S659
E
R
E
K
N
M
H
S
F
N
T
D
P
D
V
Cat
Felis silvestris
Mouse
Mus musculus
Q60848
821
95107
S643
E
R
E
K
N
I
Y
S
F
N
T
D
P
D
V
Rat
Rattus norvegicus
NP_001099841
837
97061
S659
E
R
E
K
N
I
Y
S
F
N
T
D
P
E
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505934
823
95454
K645
A
R
E
E
N
M
H
K
F
N
T
D
P
E
V
Chicken
Gallus gallus
XP_421626
822
94772
Q643
D
R
E
E
N
M
H
Q
F
N
N
D
P
E
V
Frog
Xenopus laevis
NP_001086442
838
97155
S663
D
R
E
E
N
M
R
S
F
N
T
D
P
D
V
Zebra Danio
Brachydanio rerio
NP_001032178
853
98163
K676
D
R
D
E
N
M
K
K
F
S
S
D
P
E
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P43610
853
96947
F665
R
K
D
Q
L
E
K
F
N
S
S
K
D
K
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.8
94.9
N.A.
89.7
91.6
N.A.
84.1
80.5
72.4
65
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
100
99.4
97.3
N.A.
95.5
96
N.A.
92.2
90
86.5
80.5
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
93.3
93.3
N.A.
80
86.6
N.A.
80
73.3
73.3
53.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
93.3
100
N.A.
100
100
N.A.
86.6
86.6
93.3
86.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
34.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
53.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
28
0
19
0
0
0
0
0
0
0
0
91
10
28
0
% D
% Glu:
55
0
82
37
0
10
0
0
0
0
0
0
0
64
0
% E
% Phe:
0
0
0
0
0
0
0
10
91
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
55
0
0
0
0
0
0
0
10
% H
% Ile:
0
0
0
0
0
19
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
10
0
55
0
0
19
19
0
0
0
10
0
10
0
% K
% Leu:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
73
0
0
0
0
10
0
0
0
0
% M
% Asn:
0
0
0
0
91
0
0
0
10
82
10
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
91
0
0
% P
% Gln:
0
0
0
10
0
0
0
10
0
0
0
0
0
0
0
% Q
% Arg:
10
91
0
0
0
0
10
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
64
0
19
19
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
64
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
91
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
19
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _