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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOPORS All Species: 12.42
Human Site: S626 Identified Species: 27.33
UniProt: Q9NS56 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NS56 NP_005793.2 1045 119198 S626 H G K K R M K S K R S R S R E
Chimpanzee Pan troglodytes XP_001156839 1045 119283 S626 H G K K R M K S K R S R S R E
Rhesus Macaque Macaca mulatta XP_001092273 1081 123033 S662 H G K K R M K S K R S R S R E
Dog Lupus familis XP_538699 976 111922 S567 R S R S R E S S R P R G R R D
Cat Felis silvestris
Mouse Mus musculus Q80Z37 1033 117063 R624 K H G K K R L R N K R S R S R
Rat Rattus norvegicus NP_001102128 1042 117774 K627 G K K R L K N K R S R S R E S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520205 899 102811 P490 K E S A S S S P R N G E S S S
Chicken Gallus gallus XP_424920 879 98464 R470 K C Q S K K R R S R S R D G S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_687895 999 114744 S590 D L L D R S R S R S N S R I S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_394020 767 88405 F358 P S T V G Q T F Q L E I P Y N
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_782164 866 98741 E457 S D G K R E K E T K G R L S R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 95.5 87.3 N.A. 86.1 85.5 N.A. 49 30.7 N.A. 33.9 N.A. N.A. 25.3 N.A. 25.8
Protein Similarity: 100 99.9 96.1 90.2 N.A. 91.3 90.8 N.A. 62 46.5 N.A. 50.5 N.A. N.A. 42 N.A. 41.6
P-Site Identity: 100 100 100 20 N.A. 6.6 6.6 N.A. 6.6 20 N.A. 13.3 N.A. N.A. 0 N.A. 26.6
P-Site Similarity: 100 100 100 40 N.A. 20 20 N.A. 13.3 40 N.A. 33.3 N.A. N.A. 6.6 N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 10 0 10 0 0 0 0 0 0 0 0 10 0 10 % D
% Glu: 0 10 0 0 0 19 0 10 0 0 10 10 0 10 28 % E
% Phe: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % F
% Gly: 10 28 19 0 10 0 0 0 0 0 19 10 0 10 0 % G
% His: 28 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 10 0 10 0 % I
% Lys: 28 10 37 46 19 19 37 10 28 19 0 0 0 0 0 % K
% Leu: 0 10 10 0 10 0 10 0 0 10 0 0 10 0 0 % L
% Met: 0 0 0 0 0 28 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 10 0 10 10 10 0 0 0 10 % N
% Pro: 10 0 0 0 0 0 0 10 0 10 0 0 10 0 0 % P
% Gln: 0 0 10 0 0 10 0 0 10 0 0 0 0 0 0 % Q
% Arg: 10 0 10 10 55 10 19 19 37 37 28 46 37 37 19 % R
% Ser: 10 19 10 19 10 19 19 46 10 19 37 28 37 28 37 % S
% Thr: 0 0 10 0 0 0 10 0 10 0 0 0 0 0 0 % T
% Val: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _