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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PNPLA3
All Species:
22.12
Human Site:
S130
Identified Species:
54.07
UniProt:
Q9NST1
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NST1
NP_079501.2
481
52865
S130
D
G
E
N
V
L
V
S
D
F
R
S
K
D
E
Chimpanzee
Pan troglodytes
XP_515184
562
61839
S211
D
W
E
N
V
L
V
S
D
F
R
S
K
D
E
Rhesus Macaque
Macaca mulatta
XP_001109144
481
53057
S130
D
G
E
N
V
L
V
S
D
F
Q
S
K
D
E
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q91WW7
413
45753
N80
V
R
K
A
R
S
R
N
I
G
T
L
H
P
F
Rat
Rattus norvegicus
P0C548
478
52548
S130
D
G
E
N
V
I
I
S
H
F
S
S
K
D
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509841
390
42660
C58
L
S
C
A
V
H
L
C
Q
I
P
L
D
L
L
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001087449
506
56166
S130
D
G
E
N
V
L
V
S
E
F
N
S
K
E
E
Zebra Danio
Brachydanio rerio
NP_001002338
473
52215
S130
D
G
Q
N
V
L
V
S
D
F
S
S
K
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q11186
621
69345
D131
D
H
E
N
V
I
I
D
E
Y
R
S
N
A
D
Sea Urchin
Strong. purpuratus
XP_787685
643
72506
Y123
Q
N
V
M
V
S
E
Y
E
T
R
K
D
L
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
78.2
92.7
N.A.
N.A.
60
42.2
N.A.
43.8
N.A.
42
40.1
N.A.
N.A.
N.A.
28.6
30.4
Protein Similarity:
100
79.8
95
N.A.
N.A.
70.2
58.8
N.A.
57.5
N.A.
58.7
56.9
N.A.
N.A.
N.A.
45.4
47.2
P-Site Identity:
100
93.3
93.3
N.A.
N.A.
0
73.3
N.A.
6.6
N.A.
80
80
N.A.
N.A.
N.A.
40
13.3
P-Site Similarity:
100
93.3
100
N.A.
N.A.
13.3
86.6
N.A.
13.3
N.A.
93.3
93.3
N.A.
N.A.
N.A.
73.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
20
0
0
0
0
0
0
0
0
0
10
0
% A
% Cys:
0
0
10
0
0
0
0
10
0
0
0
0
0
0
0
% C
% Asp:
70
0
0
0
0
0
0
10
40
0
0
0
20
40
10
% D
% Glu:
0
0
60
0
0
0
10
0
30
0
0
0
0
20
60
% E
% Phe:
0
0
0
0
0
0
0
0
0
60
0
0
0
0
10
% F
% Gly:
0
50
0
0
0
0
0
0
0
10
0
0
0
0
0
% G
% His:
0
10
0
0
0
10
0
0
10
0
0
0
10
0
0
% H
% Ile:
0
0
0
0
0
20
20
0
10
10
0
0
0
0
0
% I
% Lys:
0
0
10
0
0
0
0
0
0
0
0
10
60
0
0
% K
% Leu:
10
0
0
0
0
50
10
0
0
0
0
20
0
20
10
% L
% Met:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
10
% M
% Asn:
0
10
0
70
0
0
0
10
0
0
10
0
10
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
10
0
0
10
0
% P
% Gln:
10
0
10
0
0
0
0
0
10
0
10
0
0
0
0
% Q
% Arg:
0
10
0
0
10
0
10
0
0
0
40
0
0
0
0
% R
% Ser:
0
10
0
0
0
20
0
60
0
0
20
70
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
10
10
0
0
0
0
% T
% Val:
10
0
10
0
90
0
50
0
0
0
0
0
0
0
0
% V
% Trp:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
10
0
10
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _