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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PNPLA3
All Species:
18.79
Human Site:
S185
Identified Species:
45.93
UniProt:
Q9NST1
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NST1
NP_079501.2
481
52865
S185
A
K
T
T
I
T
V
S
P
F
Y
G
E
Y
D
Chimpanzee
Pan troglodytes
XP_515184
562
61839
S266
A
K
T
T
I
I
V
S
P
F
Y
G
E
Y
D
Rhesus Macaque
Macaca mulatta
XP_001109144
481
53057
S185
A
K
T
T
I
T
V
S
P
F
Y
G
E
Y
D
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q91WW7
413
45753
K135
L
V
S
E
F
H
S
K
D
E
V
V
D
A
L
Rat
Rattus norvegicus
P0C548
478
52548
S185
L
K
N
T
I
T
V
S
P
F
S
G
E
S
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509841
390
42660
K113
A
H
Q
L
V
S
G
K
L
C
I
S
L
T
R
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001087449
506
56166
S185
L
K
N
T
I
T
V
S
P
F
S
G
E
S
D
Zebra Danio
Brachydanio rerio
NP_001002338
473
52215
S185
L
K
N
T
I
T
V
S
P
F
S
G
E
S
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q11186
621
69345
P186
E
H
T
V
T
V
S
P
F
S
G
E
S
D
I
Sea Urchin
Strong. purpuratus
XP_787685
643
72506
P178
C
K
T
I
T
V
S
P
L
S
G
E
A
D
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
78.2
92.7
N.A.
N.A.
60
42.2
N.A.
43.8
N.A.
42
40.1
N.A.
N.A.
N.A.
28.6
30.4
Protein Similarity:
100
79.8
95
N.A.
N.A.
70.2
58.8
N.A.
57.5
N.A.
58.7
56.9
N.A.
N.A.
N.A.
45.4
47.2
P-Site Identity:
100
93.3
100
N.A.
N.A.
0
73.3
N.A.
6.6
N.A.
73.3
73.3
N.A.
N.A.
N.A.
6.6
13.3
P-Site Similarity:
100
93.3
100
N.A.
N.A.
13.3
73.3
N.A.
20
N.A.
73.3
73.3
N.A.
N.A.
N.A.
6.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
40
0
0
0
0
0
0
0
0
0
0
0
10
10
0
% A
% Cys:
10
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
10
0
0
0
10
20
60
% D
% Glu:
10
0
0
10
0
0
0
0
0
10
0
20
60
0
0
% E
% Phe:
0
0
0
0
10
0
0
0
10
60
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
10
0
0
0
20
60
0
0
0
% G
% His:
0
20
0
0
0
10
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
10
60
10
0
0
0
0
10
0
0
0
20
% I
% Lys:
0
70
0
0
0
0
0
20
0
0
0
0
0
0
0
% K
% Leu:
40
0
0
10
0
0
0
0
20
0
0
0
10
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
30
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
20
60
0
0
0
0
0
0
% P
% Gln:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% R
% Ser:
0
0
10
0
0
10
30
60
0
20
30
10
10
30
0
% S
% Thr:
0
0
50
60
20
50
0
0
0
0
0
0
0
10
0
% T
% Val:
0
10
0
10
10
20
60
0
0
0
10
10
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
30
0
0
30
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _