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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PNPLA3
All Species:
10.61
Human Site:
S448
Identified Species:
25.93
UniProt:
Q9NST1
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NST1
NP_079501.2
481
52865
S448
K
A
E
A
T
P
R
S
I
L
R
S
S
L
N
Chimpanzee
Pan troglodytes
XP_515184
562
61839
S529
K
A
E
A
A
P
R
S
I
L
R
S
S
L
N
Rhesus Macaque
Macaca mulatta
XP_001109144
481
53057
S448
K
A
E
A
T
P
R
S
I
L
R
S
S
L
N
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q91WW7
413
45753
T383
T
M
C
L
L
P
S
T
R
S
R
A
S
K
D
Rat
Rattus norvegicus
P0C548
478
52548
C443
Q
L
L
L
G
L
F
C
T
N
V
A
F
P
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509841
390
42660
A360
P
V
E
S
A
F
I
A
L
Q
R
L
I
E
W
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001087449
506
56166
F448
L
E
S
W
V
F
D
F
S
C
P
S
H
L
W
Zebra Danio
Brachydanio rerio
NP_001002338
473
52215
F441
L
D
S
Y
K
W
T
F
P
N
N
I
H
T
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q11186
621
69345
N489
A
G
K
I
T
P
N
N
S
E
N
Q
F
D
E
Sea Urchin
Strong. purpuratus
XP_787685
643
72506
A537
Q
F
K
M
D
V
Q
A
E
G
L
P
D
C
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
78.2
92.7
N.A.
N.A.
60
42.2
N.A.
43.8
N.A.
42
40.1
N.A.
N.A.
N.A.
28.6
30.4
Protein Similarity:
100
79.8
95
N.A.
N.A.
70.2
58.8
N.A.
57.5
N.A.
58.7
56.9
N.A.
N.A.
N.A.
45.4
47.2
P-Site Identity:
100
93.3
100
N.A.
N.A.
20
0
N.A.
13.3
N.A.
13.3
0
N.A.
N.A.
N.A.
13.3
0
P-Site Similarity:
100
93.3
100
N.A.
N.A.
40
13.3
N.A.
33.3
N.A.
13.3
0
N.A.
N.A.
N.A.
26.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
30
0
30
20
0
0
20
0
0
0
20
0
0
0
% A
% Cys:
0
0
10
0
0
0
0
10
0
10
0
0
0
10
0
% C
% Asp:
0
10
0
0
10
0
10
0
0
0
0
0
10
10
10
% D
% Glu:
0
10
40
0
0
0
0
0
10
10
0
0
0
10
10
% E
% Phe:
0
10
0
0
0
20
10
20
0
0
0
0
20
0
0
% F
% Gly:
0
10
0
0
10
0
0
0
0
10
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
20
0
0
% H
% Ile:
0
0
0
10
0
0
10
0
30
0
0
10
10
0
0
% I
% Lys:
30
0
20
0
10
0
0
0
0
0
0
0
0
10
0
% K
% Leu:
20
10
10
20
10
10
0
0
10
30
10
10
0
40
0
% L
% Met:
0
10
0
10
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
10
10
0
20
20
0
0
0
30
% N
% Pro:
10
0
0
0
0
50
0
0
10
0
10
10
0
10
10
% P
% Gln:
20
0
0
0
0
0
10
0
0
10
0
10
0
0
0
% Q
% Arg:
0
0
0
0
0
0
30
0
10
0
50
0
0
0
0
% R
% Ser:
0
0
20
10
0
0
10
30
20
10
0
40
40
0
0
% S
% Thr:
10
0
0
0
30
0
10
10
10
0
0
0
0
10
10
% T
% Val:
0
10
0
0
10
10
0
0
0
0
10
0
0
0
10
% V
% Trp:
0
0
0
10
0
10
0
0
0
0
0
0
0
0
20
% W
% Tyr:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _