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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT3
All Species:
1.52
Human Site:
S114
Identified Species:
3.33
UniProt:
Q9NTG7
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NTG7
NP_001017524.1
399
43573
S114
G
A
S
S
V
V
G
S
G
G
S
S
D
K
G
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001116486
345
37592
R99
F
S
S
I
K
G
G
R
R
P
I
S
F
S
V
Dog
Lupus familis
XP_848300
330
36552
F55
G
D
H
K
K
K
L
F
L
Q
D
I
A
E
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8R104
257
28804
N25
P
G
S
G
L
Y
S
N
L
Q
Q
Y
D
I
P
Rat
Rattus norvegicus
Q5RJQ4
350
39301
I56
G
I
S
T
S
A
G
I
P
D
F
R
S
P
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_420920
346
38618
W61
A
V
L
G
L
G
S
W
G
G
D
S
G
K
Q
Frog
Xenopus laevis
NP_001089567
350
39249
C74
P
N
K
C
P
M
G
C
K
D
L
A
D
I
L
Zebra Danio
Brachydanio rerio
Q7ZVK3
379
42296
L60
G
D
K
V
L
D
E
L
T
L
D
S
V
A
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650880
355
40094
G57
I
V
T
M
V
G
A
G
I
S
T
S
A
G
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21921
607
68747
T58
R
Q
R
T
E
S
T
T
S
V
S
S
E
S
W
Sea Urchin
Strong. purpuratus
XP_001186397
463
51241
R98
R
S
A
T
P
K
R
R
Q
S
S
S
A
G
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
77.9
67.4
N.A.
55.1
40.8
N.A.
N.A.
62.4
45.6
42.6
N.A.
42.8
N.A.
23.5
41.6
Protein Similarity:
100
N.A.
80.1
73.9
N.A.
58.9
55.1
N.A.
N.A.
70.6
60.1
60.6
N.A.
57.8
N.A.
37.4
54.2
P-Site Identity:
100
N.A.
20
6.6
N.A.
13.3
20
N.A.
N.A.
26.6
13.3
13.3
N.A.
13.3
N.A.
13.3
13.3
P-Site Similarity:
100
N.A.
26.6
13.3
N.A.
26.6
26.6
N.A.
N.A.
33.3
26.6
20
N.A.
26.6
N.A.
33.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
10
0
0
10
10
0
0
0
0
10
28
10
0
% A
% Cys:
0
0
0
10
0
0
0
10
0
0
0
0
0
0
0
% C
% Asp:
0
19
0
0
0
10
0
0
0
19
28
0
28
0
0
% D
% Glu:
0
0
0
0
10
0
10
0
0
0
0
0
10
10
0
% E
% Phe:
10
0
0
0
0
0
0
10
0
0
10
0
10
0
0
% F
% Gly:
37
10
0
19
0
28
37
10
19
19
0
0
10
19
10
% G
% His:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
10
10
0
10
0
0
0
10
10
0
10
10
0
19
10
% I
% Lys:
0
0
19
10
19
19
0
0
10
0
0
0
0
19
0
% K
% Leu:
0
0
10
0
28
0
10
10
19
10
10
0
0
0
19
% L
% Met:
0
0
0
10
0
10
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
0
0
0
0
0
10
0
0
0
0
0
0
10
% N
% Pro:
19
0
0
0
19
0
0
0
10
10
0
0
0
10
10
% P
% Gln:
0
10
0
0
0
0
0
0
10
19
10
0
0
0
10
% Q
% Arg:
19
0
10
0
0
0
10
19
10
0
0
10
0
0
10
% R
% Ser:
0
19
37
10
10
10
19
10
10
19
28
64
10
19
10
% S
% Thr:
0
0
10
28
0
0
10
10
10
0
10
0
0
0
0
% T
% Val:
0
19
0
10
19
10
0
0
0
10
0
0
10
0
10
% V
% Trp:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
10
% W
% Tyr:
0
0
0
0
0
10
0
0
0
0
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _