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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC4
All Species:
37.58
Human Site:
S466
Identified Species:
51.67
UniProt:
Q9NTJ3
Number Species:
16
Phosphosite Substitution
Charge Score:
0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NTJ3
NP_001002800.1
1288
147182
S466
K
L
K
E
V
M
D
S
L
K
Q
E
T
Q
G
Chimpanzee
Pan troglodytes
XP_001157958
1288
147223
S466
K
L
K
E
V
M
D
S
L
K
Q
E
T
Q
G
Rhesus Macaque
Macaca mulatta
XP_001099428
1287
147121
S465
K
L
K
E
V
M
D
S
L
K
Q
E
T
Q
G
Dog
Lupus familis
XP_535848
1288
147094
S466
K
L
K
E
V
M
D
S
L
K
Q
E
T
Q
G
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG47
1286
146876
S464
K
L
K
E
V
M
D
S
L
K
Q
E
T
Q
G
Rat
Rattus norvegicus
Q9Z1M9
1233
143186
Q423
E
T
E
A
K
I
K
Q
K
L
R
E
I
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510551
1069
122201
A313
T
L
K
E
R
K
V
A
I
G
E
L
E
T
K
Chicken
Gallus gallus
NP_989849
1274
145838
S437
K
L
K
Q
V
M
S
S
L
Q
E
E
T
R
E
Frog
Xenopus laevis
P50532
1290
146971
S460
K
L
K
N
V
M
D
S
L
K
K
E
T
Q
G
Zebra Danio
Brachydanio rerio
NP_775360
1289
145687
S465
K
L
A
E
V
M
E
S
L
K
E
E
T
K
G
Tiger Blowfish
Takifugu rubipres
NP_001027927
1326
150958
S462
K
L
K
D
V
M
E
S
L
K
E
E
T
S
G
Fruit Fly
Dros. melanogaster
Q9VJE5
1690
189046
M717
Q
E
K
L
V
R
E
M
T
E
N
A
I
N
Q
Honey Bee
Apis mellifera
XP_396862
1282
148175
E402
I
L
E
K
L
M
I
E
L
S
K
K
T
K
P
Nematode Worm
Caenorhab. elegans
Q20060
1549
176553
E472
E
A
D
K
N
L
D
E
F
E
K
R
S
E
A
Sea Urchin
Strong. purpuratus
XP_797583
1289
146235
R466
E
I
G
E
L
E
K
R
K
A
S
L
E
E
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJL0
1241
141112
I408
K
L
E
E
I
K
A
I
A
K
V
E
T
E
G
Baker's Yeast
Sacchar. cerevisiae
Q12267
1418
162171
S539
I
L
D
D
I
K
L
S
L
K
D
K
T
K
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
94
N.A.
89.5
24
N.A.
67.8
75.3
76.9
67.9
66.7
20.1
45.9
29.9
48.1
Protein Similarity:
100
99.6
98.9
96.5
N.A.
94.8
47.5
N.A.
75
86.3
87.5
83.5
81.2
40.2
63.9
47.5
65.4
P-Site Identity:
100
100
100
100
N.A.
100
6.6
N.A.
20
60
86.6
73.3
73.3
13.3
26.6
6.6
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
40
N.A.
40
86.6
93.3
93.3
93.3
33.3
66.6
53.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.3
35.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
58.7
55.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
46.6
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
6
6
6
0
0
6
6
6
6
0
6
0
0
6
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
12
12
0
0
42
0
0
0
6
0
0
0
0
% D
% Glu:
18
6
18
53
0
6
18
12
0
12
24
65
12
24
12
% E
% Phe:
0
0
0
0
0
0
0
0
6
0
0
0
0
0
0
% F
% Gly:
0
0
6
0
0
0
0
0
0
6
0
0
0
0
53
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
12
6
0
0
12
6
6
6
6
0
0
0
12
0
0
% I
% Lys:
59
0
59
12
6
18
12
0
12
59
18
12
0
18
12
% K
% Leu:
0
77
0
6
12
6
6
0
65
6
0
12
0
0
0
% L
% Met:
0
0
0
0
0
59
0
6
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
6
6
0
0
0
0
0
6
0
0
6
6
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
6
% P
% Gln:
6
0
0
6
0
0
0
6
0
6
30
0
0
36
6
% Q
% Arg:
0
0
0
0
6
6
0
6
0
0
6
6
0
6
0
% R
% Ser:
0
0
0
0
0
0
6
59
0
6
6
0
6
6
0
% S
% Thr:
6
6
0
0
0
0
0
0
6
0
0
0
71
6
0
% T
% Val:
0
0
0
0
59
0
6
0
0
0
6
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _