KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC4
All Species:
31.52
Human Site:
S491
Identified Species:
43.33
UniProt:
Q9NTJ3
Number Species:
16
Phosphosite Substitution
Charge Score:
0.31
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NTJ3
NP_001002800.1
1288
147182
S491
E
L
M
G
F
S
K
S
V
N
E
A
R
S
K
Chimpanzee
Pan troglodytes
XP_001157958
1288
147223
S491
E
L
M
G
F
S
K
S
V
N
E
A
R
S
K
Rhesus Macaque
Macaca mulatta
XP_001099428
1287
147121
S490
E
L
M
G
F
S
K
S
V
N
E
A
R
S
K
Dog
Lupus familis
XP_535848
1288
147094
S491
E
L
M
G
F
S
K
S
V
N
E
A
R
S
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG47
1286
146876
S489
E
L
M
G
F
N
K
S
V
N
E
A
R
S
K
Rat
Rattus norvegicus
Q9Z1M9
1233
143186
S448
Y
I
T
T
S
K
Q
S
L
E
E
Q
K
K
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510551
1069
122201
V338
K
E
N
K
L
E
K
V
A
K
E
E
M
G
I
Chicken
Gallus gallus
NP_989849
1274
145838
T462
E
L
M
E
F
C
K
T
V
N
D
A
R
S
K
Frog
Xenopus laevis
P50532
1290
146971
T485
E
L
M
E
I
S
K
T
V
N
E
A
R
S
K
Zebra Danio
Brachydanio rerio
NP_775360
1289
145687
S490
E
L
L
E
L
S
K
S
V
N
E
T
R
S
R
Tiger Blowfish
Takifugu rubipres
NP_001027927
1326
150958
A487
E
L
M
E
L
S
K
A
V
N
E
T
R
S
R
Fruit Fly
Dros. melanogaster
Q9VJE5
1690
189046
E742
Q
L
A
L
K
Q
N
E
L
E
D
F
Q
K
K
Honey Bee
Apis mellifera
XP_396862
1282
148175
D427
E
L
I
I
L
R
K
D
V
D
E
A
R
A
A
Nematode Worm
Caenorhab. elegans
Q20060
1549
176553
E497
T
W
A
Q
K
S
N
E
F
N
K
V
R
G
E
Sea Urchin
Strong. purpuratus
XP_797583
1289
146235
E491
I
M
A
S
L
K
T
E
T
K
G
L
Q
A
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJL0
1241
141112
D433
E
L
E
P
W
E
K
D
L
I
V
H
R
G
K
Baker's Yeast
Sacchar. cerevisiae
Q12267
1418
162171
Q564
E
L
E
P
W
D
L
Q
L
Q
E
K
E
S
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
94
N.A.
89.5
24
N.A.
67.8
75.3
76.9
67.9
66.7
20.1
45.9
29.9
48.1
Protein Similarity:
100
99.6
98.9
96.5
N.A.
94.8
47.5
N.A.
75
86.3
87.5
83.5
81.2
40.2
63.9
47.5
65.4
P-Site Identity:
100
100
100
100
N.A.
93.3
13.3
N.A.
13.3
73.3
80
66.6
66.6
13.3
46.6
20
0
P-Site Similarity:
100
100
100
100
N.A.
100
40
N.A.
20
86.6
86.6
80
80
40
66.6
33.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.3
35.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
58.7
55.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
33.3
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
18
0
0
0
0
6
6
0
0
48
0
12
6
% A
% Cys:
0
0
0
0
0
6
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
6
0
12
0
6
12
0
0
0
0
% D
% Glu:
71
6
12
24
0
12
0
18
0
12
71
6
6
0
12
% E
% Phe:
0
0
0
0
36
0
0
0
6
0
0
6
0
0
0
% F
% Gly:
0
0
0
30
0
0
0
0
0
0
6
0
0
18
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
6
0
0
0
% H
% Ile:
6
6
6
6
6
0
0
0
0
6
0
0
0
0
6
% I
% Lys:
6
0
0
6
12
12
71
0
0
12
6
6
6
12
53
% K
% Leu:
0
77
6
6
30
0
6
0
24
0
0
6
0
0
6
% L
% Met:
0
6
48
0
0
0
0
0
0
0
0
0
6
0
0
% M
% Asn:
0
0
6
0
0
6
12
0
0
59
0
0
0
0
0
% N
% Pro:
0
0
0
12
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
6
0
0
6
0
6
6
6
0
6
0
6
12
0
6
% Q
% Arg:
0
0
0
0
0
6
0
0
0
0
0
0
71
0
12
% R
% Ser:
0
0
0
6
6
48
0
42
0
0
0
0
0
59
0
% S
% Thr:
6
0
6
6
0
0
6
12
6
0
0
12
0
0
0
% T
% Val:
0
0
0
0
0
0
0
6
59
0
6
6
0
0
0
% V
% Trp:
0
6
0
0
12
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
6
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _