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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SMC4 All Species: 41.52
Human Site: S589 Identified Species: 57.08
UniProt: Q9NTJ3 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NTJ3 NP_001002800.1 1288 147182 S589 K V E E A K S S L A M N R S R
Chimpanzee Pan troglodytes XP_001157958 1288 147223 S589 K V E E A K S S L A M N R S R
Rhesus Macaque Macaca mulatta XP_001099428 1287 147121 S588 K V E E A K S S L A M N R S R
Dog Lupus familis XP_535848 1288 147094 S589 K V E E A K S S L A M N R S R
Cat Felis silvestris
Mouse Mus musculus Q8CG47 1286 146876 S587 K V E E A K S S L A M N R S R
Rat Rattus norvegicus Q9Z1M9 1233 143186 A544 V L G K N M D A I I V D S E K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510551 1069 122201 K433 E C V N F L K K Q N I G V A T
Chicken Gallus gallus NP_989849 1274 145838 S560 K V E E A K S S L A Q H R S R
Frog Xenopus laevis P50532 1290 146971 S583 K V E E A R S S L S A N R S R
Zebra Danio Brachydanio rerio NP_775360 1289 145687 S588 K V A E A K S S L S S N R S R
Tiger Blowfish Takifugu rubipres NP_001027927 1326 150958 S585 K V D E A K S S L S S N R S R
Fruit Fly Dros. melanogaster Q9VJE5 1690 189046 Q844 Q L E Q L Q Q Q A A A S G E E
Honey Bee Apis mellifera XP_396862 1282 148175 A525 S F E E Q K L A M Q A N K S R
Nematode Worm Caenorhab. elegans Q20060 1549 176553 Q595 R L E T L R Q Q N S S C S S S
Sea Urchin Strong. purpuratus XP_797583 1289 146235 S588 K V Q E A R S S M Q S A K D R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FJL0 1241 141112 A531 K V A E L K S A M N S E K S Q
Baker's Yeast Sacchar. cerevisiae Q12267 1418 162171 S662 R A M E A R S S L S K A Q N K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 98.3 94 N.A. 89.5 24 N.A. 67.8 75.3 76.9 67.9 66.7 20.1 45.9 29.9 48.1
Protein Similarity: 100 99.6 98.9 96.5 N.A. 94.8 47.5 N.A. 75 86.3 87.5 83.5 81.2 40.2 63.9 47.5 65.4
P-Site Identity: 100 100 100 100 N.A. 100 0 N.A. 0 86.6 80 80 80 13.3 40 13.3 46.6
P-Site Similarity: 100 100 100 100 N.A. 100 46.6 N.A. 20 93.3 93.3 86.6 93.3 46.6 60 40 73.3
Percent
Protein Identity: N.A. N.A. N.A. 41.3 35.6 N.A.
Protein Similarity: N.A. N.A. N.A. 58.7 55.4 N.A.
P-Site Identity: N.A. N.A. N.A. 40 33.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 66.6 73.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 6 12 0 65 0 0 18 6 42 18 12 0 6 0 % A
% Cys: 0 6 0 0 0 0 0 0 0 0 0 6 0 0 0 % C
% Asp: 0 0 6 0 0 0 6 0 0 0 0 6 0 6 0 % D
% Glu: 6 0 59 77 0 0 0 0 0 0 0 6 0 12 6 % E
% Phe: 0 6 0 0 6 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 6 0 0 0 0 0 0 0 0 6 6 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 6 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 6 6 6 0 0 0 0 % I
% Lys: 65 0 0 6 0 59 6 6 0 0 6 0 18 0 12 % K
% Leu: 0 18 0 0 18 6 6 0 59 0 0 0 0 0 0 % L
% Met: 0 0 6 0 0 6 0 0 18 0 30 0 0 0 0 % M
% Asn: 0 0 0 6 6 0 0 0 6 12 0 53 0 6 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 6 0 6 6 6 6 12 12 6 12 6 0 6 0 6 % Q
% Arg: 12 0 0 0 0 24 0 0 0 0 0 0 53 0 65 % R
% Ser: 6 0 0 0 0 0 71 65 0 30 30 6 12 71 6 % S
% Thr: 0 0 0 6 0 0 0 0 0 0 0 0 0 0 6 % T
% Val: 6 65 6 0 0 0 0 0 0 0 6 0 6 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _