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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC4
All Species:
42.42
Human Site:
S595
Identified Species:
58.33
UniProt:
Q9NTJ3
Number Species:
16
Phosphosite Substitution
Charge Score:
0.19
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NTJ3
NP_001002800.1
1288
147182
S595
S
S
L
A
M
N
R
S
R
G
K
V
L
D
A
Chimpanzee
Pan troglodytes
XP_001157958
1288
147223
S595
S
S
L
A
M
N
R
S
R
G
K
V
L
D
A
Rhesus Macaque
Macaca mulatta
XP_001099428
1287
147121
S594
S
S
L
A
M
N
R
S
R
G
K
V
L
D
A
Dog
Lupus familis
XP_535848
1288
147094
S595
S
S
L
A
M
N
R
S
R
G
K
V
L
D
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG47
1286
146876
S593
S
S
L
A
M
N
R
S
R
G
K
V
L
D
A
Rat
Rattus norvegicus
Q9Z1M9
1233
143186
E550
D
A
I
I
V
D
S
E
K
T
G
R
D
C
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510551
1069
122201
A439
K
K
Q
N
I
G
V
A
T
F
I
G
L
D
K
Chicken
Gallus gallus
NP_989849
1274
145838
S566
S
S
L
A
Q
H
R
S
R
G
K
V
L
E
A
Frog
Xenopus laevis
P50532
1290
146971
S589
S
S
L
S
A
N
R
S
R
G
K
V
L
D
A
Zebra Danio
Brachydanio rerio
NP_775360
1289
145687
S594
S
S
L
S
S
N
R
S
R
S
K
V
L
D
T
Tiger Blowfish
Takifugu rubipres
NP_001027927
1326
150958
S591
S
S
L
S
S
N
R
S
R
G
K
V
L
D
A
Fruit Fly
Dros. melanogaster
Q9VJE5
1690
189046
E850
Q
Q
A
A
A
S
G
E
E
G
S
K
T
V
A
Honey Bee
Apis mellifera
XP_396862
1282
148175
S531
L
A
M
Q
A
N
K
S
R
N
K
I
I
D
N
Nematode Worm
Caenorhab. elegans
Q20060
1549
176553
S601
Q
Q
N
S
S
C
S
S
S
N
K
V
I
Q
A
Sea Urchin
Strong. purpuratus
XP_797583
1289
146235
D594
S
S
M
Q
S
A
K
D
R
G
F
L
I
S
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJL0
1241
141112
S537
S
A
M
N
S
E
K
S
Q
N
E
V
L
K
A
Baker's Yeast
Sacchar. cerevisiae
Q12267
1418
162171
N668
S
S
L
S
K
A
Q
N
K
S
K
V
L
T
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
94
N.A.
89.5
24
N.A.
67.8
75.3
76.9
67.9
66.7
20.1
45.9
29.9
48.1
Protein Similarity:
100
99.6
98.9
96.5
N.A.
94.8
47.5
N.A.
75
86.3
87.5
83.5
81.2
40.2
63.9
47.5
65.4
P-Site Identity:
100
100
100
100
N.A.
100
0
N.A.
13.3
80
86.6
73.3
86.6
20
33.3
26.6
33.3
P-Site Similarity:
100
100
100
100
N.A.
100
33.3
N.A.
26.6
93.3
93.3
80
93.3
26.6
66.6
40
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.3
35.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
58.7
55.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
33.3
46.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
18
6
42
18
12
0
6
0
0
0
0
0
0
77
% A
% Cys:
0
0
0
0
0
6
0
0
0
0
0
0
0
6
0
% C
% Asp:
6
0
0
0
0
6
0
6
0
0
0
0
6
59
0
% D
% Glu:
0
0
0
0
0
6
0
12
6
0
6
0
0
6
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
6
6
0
0
0
0
% F
% Gly:
0
0
0
0
0
6
6
0
0
59
6
6
0
0
0
% G
% His:
0
0
0
0
0
6
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
6
6
6
0
0
0
0
0
6
6
18
0
6
% I
% Lys:
6
6
0
0
6
0
18
0
12
0
71
6
0
6
6
% K
% Leu:
6
0
59
0
0
0
0
0
0
0
0
6
71
0
0
% L
% Met:
0
0
18
0
30
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
6
12
0
53
0
6
0
18
0
0
0
0
6
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
12
12
6
12
6
0
6
0
6
0
0
0
0
6
0
% Q
% Arg:
0
0
0
0
0
0
53
0
65
0
0
6
0
0
0
% R
% Ser:
71
65
0
30
30
6
12
71
6
12
6
0
0
6
0
% S
% Thr:
0
0
0
0
0
0
0
0
6
6
0
0
6
6
6
% T
% Val:
0
0
0
0
6
0
6
0
0
0
0
71
0
6
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _