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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SMC4 All Species: 17.27
Human Site: S964 Identified Species: 23.75
UniProt: Q9NTJ3 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NTJ3 NP_001002800.1 1288 147182 S964 D L T A E L K S L E D K A A E
Chimpanzee Pan troglodytes XP_001157958 1288 147223 S964 D L T A E L K S L E D K A A E
Rhesus Macaque Macaca mulatta XP_001099428 1287 147121 S963 D L T A E L K S L E D K A A E
Dog Lupus familis XP_535848 1288 147094 S964 D L T A E L K S V E D K A A E
Cat Felis silvestris
Mouse Mus musculus Q8CG47 1286 146876 N962 D L K T E L K N I E D K A E E
Rat Rattus norvegicus Q9Z1M9 1233 143186 G900 E I R K K L G G A N K E M T H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510551 1069 122201 I773 L L Q E L K A I Q E R E H A L
Chicken Gallus gallus NP_989849 1274 145838 T935 D L T E E L T T L E D K A T E
Frog Xenopus laevis P50532 1290 146971 K958 E L T E D L K K L E E K A T T
Zebra Danio Brachydanio rerio NP_775360 1289 145687 K963 E L T E Q L K K L E E Q A G E
Tiger Blowfish Takifugu rubipres NP_001027927 1326 150958 K959 E L T E Q L K K L E D E A G E
Fruit Fly Dros. melanogaster Q9VJE5 1690 189046 Q1305 K L S G E L Q Q V Q E A N G D
Honey Bee Apis mellifera XP_396862 1282 148175 D901 N F Q K E K Q D L E V E G K E
Nematode Worm Caenorhab. elegans Q20060 1549 176553 D977 E L M E K A I D D E E V K S K
Sea Urchin Strong. purpuratus XP_797583 1289 146235 R962 K I E K E F K R L E E D A T K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FJL0 1241 141112 D906 N L H V T F K D I T Q K A F E
Baker's Yeast Sacchar. cerevisiae Q12267 1418 162171 H1039 V I E E Q L K H T K L A L A E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 98.3 94 N.A. 89.5 24 N.A. 67.8 75.3 76.9 67.9 66.7 20.1 45.9 29.9 48.1
Protein Similarity: 100 99.6 98.9 96.5 N.A. 94.8 47.5 N.A. 75 86.3 87.5 83.5 81.2 40.2 63.9 47.5 65.4
P-Site Identity: 100 100 100 93.3 N.A. 66.6 6.6 N.A. 20 73.3 53.3 53.3 60 20 26.6 13.3 33.3
P-Site Similarity: 100 100 100 100 N.A. 80 33.3 N.A. 26.6 80 73.3 80 80 60 46.6 46.6 53.3
Percent
Protein Identity: N.A. N.A. N.A. 41.3 35.6 N.A.
Protein Similarity: N.A. N.A. N.A. 58.7 55.4 N.A.
P-Site Identity: N.A. N.A. N.A. 33.3 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 46.6 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 24 0 6 6 0 6 0 0 12 65 36 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 36 0 0 0 6 0 0 18 6 0 42 6 0 0 6 % D
% Glu: 30 0 12 42 53 0 0 0 0 77 30 24 0 6 65 % E
% Phe: 0 6 0 0 0 12 0 0 0 0 0 0 0 6 0 % F
% Gly: 0 0 0 6 0 0 6 6 0 0 0 0 6 18 0 % G
% His: 0 0 6 0 0 0 0 6 0 0 0 0 6 0 6 % H
% Ile: 0 18 0 0 0 0 6 6 12 0 0 0 0 0 0 % I
% Lys: 12 0 6 18 12 12 65 18 0 6 6 48 6 6 12 % K
% Leu: 6 77 0 0 6 71 0 0 53 0 6 0 6 0 6 % L
% Met: 0 0 6 0 0 0 0 0 0 0 0 0 6 0 0 % M
% Asn: 12 0 0 0 0 0 0 6 0 6 0 0 6 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 12 0 18 0 12 6 6 6 6 6 0 0 0 % Q
% Arg: 0 0 6 0 0 0 0 6 0 0 6 0 0 0 0 % R
% Ser: 0 0 6 0 0 0 0 24 0 0 0 0 0 6 0 % S
% Thr: 0 0 48 6 6 0 6 6 6 6 0 0 0 24 6 % T
% Val: 6 0 0 6 0 0 0 0 12 0 6 6 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _