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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC4
All Species:
43.64
Human Site:
T750
Identified Species:
60
UniProt:
Q9NTJ3
Number Species:
16
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NTJ3
NP_001002800.1
1288
147182
T750
Q
I
I
E
Q
S
G
T
M
T
G
G
G
S
K
Chimpanzee
Pan troglodytes
XP_001157958
1288
147223
T750
Q
I
I
E
Q
S
G
T
M
T
G
G
G
S
K
Rhesus Macaque
Macaca mulatta
XP_001099428
1287
147121
T749
Q
I
I
E
Q
S
G
T
M
T
G
G
G
S
K
Dog
Lupus familis
XP_535848
1288
147094
T750
Q
I
I
E
Q
S
G
T
M
T
G
G
G
S
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG47
1286
146876
T748
Q
I
I
E
Q
S
G
T
M
S
G
G
G
S
K
Rat
Rattus norvegicus
Q9Z1M9
1233
143186
Q702
E
A
E
L
R
Q
V
Q
S
Q
A
H
G
L
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510551
1069
122201
R585
I
K
L
R
Q
S
V
R
E
M
K
N
T
L
E
Chicken
Gallus gallus
NP_989849
1274
145838
T721
E
I
I
E
Q
S
G
T
M
T
G
G
G
G
K
Frog
Xenopus laevis
P50532
1290
146971
T744
Q
I
I
E
Q
S
G
T
M
T
G
G
G
G
K
Zebra Danio
Brachydanio rerio
NP_775360
1289
145687
T749
Q
I
I
E
Q
A
G
T
M
T
G
G
G
G
R
Tiger Blowfish
Takifugu rubipres
NP_001027927
1326
150958
T745
Q
I
I
E
M
A
G
T
M
T
G
G
G
R
V
Fruit Fly
Dros. melanogaster
Q9VJE5
1690
189046
E1063
S
I
K
N
L
Q
E
E
V
T
K
A
K
T
E
Honey Bee
Apis mellifera
XP_396862
1282
148175
M687
L
I
E
L
S
G
T
M
S
G
G
G
R
T
V
Nematode Worm
Caenorhab. elegans
Q20060
1549
176553
S756
E
G
S
M
I
H
P
S
G
S
F
T
G
G
G
Sea Urchin
Strong. purpuratus
XP_797583
1289
146235
T749
E
L
I
E
S
S
G
T
M
S
G
G
G
K
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJL0
1241
141112
G693
G
A
L
F
E
K
S
G
T
M
S
G
G
G
G
Baker's Yeast
Sacchar. cerevisiae
Q12267
1418
162171
T820
K
L
I
D
I
S
G
T
M
S
G
G
G
N
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
94
N.A.
89.5
24
N.A.
67.8
75.3
76.9
67.9
66.7
20.1
45.9
29.9
48.1
Protein Similarity:
100
99.6
98.9
96.5
N.A.
94.8
47.5
N.A.
75
86.3
87.5
83.5
81.2
40.2
63.9
47.5
65.4
P-Site Identity:
100
100
100
100
N.A.
93.3
6.6
N.A.
13.3
86.6
93.3
80
73.3
13.3
20
6.6
60
P-Site Similarity:
100
100
100
100
N.A.
100
26.6
N.A.
26.6
93.3
93.3
93.3
80
33.3
26.6
26.6
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.3
35.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
58.7
55.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
53.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
86.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
12
0
0
0
12
0
0
0
0
6
6
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
6
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
24
0
12
59
6
0
6
6
6
0
0
0
0
0
12
% E
% Phe:
0
0
0
6
0
0
0
0
0
0
6
0
0
0
0
% F
% Gly:
6
6
0
0
0
6
65
6
6
6
71
77
83
30
12
% G
% His:
0
0
0
0
0
6
0
0
0
0
0
6
0
0
6
% H
% Ile:
6
65
65
0
12
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
6
6
6
0
0
6
0
0
0
0
12
0
6
6
42
% K
% Leu:
6
12
12
12
6
0
0
0
0
0
0
0
0
12
0
% L
% Met:
0
0
0
6
6
0
0
6
65
12
0
0
0
0
0
% M
% Asn:
0
0
0
6
0
0
0
0
0
0
0
6
0
6
0
% N
% Pro:
0
0
0
0
0
0
6
0
0
0
0
0
0
0
0
% P
% Gln:
48
0
0
0
53
12
0
6
0
6
0
0
0
0
12
% Q
% Arg:
0
0
0
6
6
0
0
6
0
0
0
0
6
6
6
% R
% Ser:
6
0
6
0
12
59
6
6
12
24
6
0
0
30
0
% S
% Thr:
0
0
0
0
0
0
6
65
6
53
0
6
6
12
0
% T
% Val:
0
0
0
0
0
0
12
0
6
0
0
0
0
0
12
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _