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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RNF146 All Species: 10.61
Human Site: S246 Identified Species: 25.93
UniProt: Q9NTX7 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NTX7 NP_112225.2 359 38950 S246 A S T S L E D S F A H L Q L S
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001106451 359 38833 S245 A S T S L E D S F A H L Q L S
Dog Lupus familis XP_533493 358 38546 S245 A S T S L E D S F A H L H L G
Cat Felis silvestris
Mouse Mus musculus Q9CZW6 359 38916 E246 P D A G I S L E D S F A H L Q
Rat Rattus norvegicus Q5XIK5 352 38206 A239 P V T P S P D A G A S L E D S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_423089 352 38139 A239 P S T P S P D A S T S L E N S
Frog Xenopus laevis NP_001085469 314 34753 S202 S S A D G A D S M A A L G D S
Zebra Danio Brachydanio rerio NP_956148 364 38767 I251 A P I R P P T I L G G H L T S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623395 287 32639 K175 D L Y N V P K K G V A G L R L
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_782343 417 46375 P286 N P S P A D N P P P T Y A K P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 98.3 91.3 N.A. 92.7 89.9 N.A. N.A. 83.8 61.2 47.7 N.A. N.A. 37.3 N.A. 34.5
Protein Similarity: 100 N.A. 99.1 94.7 N.A. 94.9 93.5 N.A. N.A. 89.6 70.1 61.5 N.A. N.A. 52.6 N.A. 50.1
P-Site Identity: 100 N.A. 100 86.6 N.A. 6.6 33.3 N.A. N.A. 33.3 40 13.3 N.A. N.A. 0 N.A. 0
P-Site Similarity: 100 N.A. 100 86.6 N.A. 20 46.6 N.A. N.A. 46.6 46.6 13.3 N.A. N.A. 13.3 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 40 0 20 0 10 10 0 20 0 50 20 10 10 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 10 0 10 0 10 60 0 10 0 0 0 0 20 0 % D
% Glu: 0 0 0 0 0 30 0 10 0 0 0 0 20 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 30 0 10 0 0 0 0 % F
% Gly: 0 0 0 10 10 0 0 0 20 10 10 10 10 0 10 % G
% His: 0 0 0 0 0 0 0 0 0 0 30 10 20 0 0 % H
% Ile: 0 0 10 0 10 0 0 10 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 10 10 0 0 0 0 0 10 0 % K
% Leu: 0 10 0 0 30 0 10 0 10 0 0 60 20 40 10 % L
% Met: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % M
% Asn: 10 0 0 10 0 0 10 0 0 0 0 0 0 10 0 % N
% Pro: 30 20 0 30 10 40 0 10 10 10 0 0 0 0 10 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 20 0 10 % Q
% Arg: 0 0 0 10 0 0 0 0 0 0 0 0 0 10 0 % R
% Ser: 10 50 10 30 20 10 0 40 10 10 20 0 0 0 60 % S
% Thr: 0 0 50 0 0 0 10 0 0 10 10 0 0 10 0 % T
% Val: 0 10 0 0 10 0 0 0 0 10 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 10 0 0 0 0 0 0 0 0 10 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _