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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMEM106B
All Species:
26.36
Human Site:
S134
Identified Species:
64.44
UniProt:
Q9NUM4
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NUM4
NP_060844.2
274
31127
S134
G
V
K
S
A
Y
V
S
Y
D
V
Q
K
R
T
Chimpanzee
Pan troglodytes
XP_518973
332
37144
S192
G
V
K
S
A
Y
V
S
Y
D
V
Q
K
R
T
Rhesus Macaque
Macaca mulatta
XP_001082836
363
40099
S223
G
V
K
S
A
Y
V
S
Y
D
V
Q
K
R
T
Dog
Lupus familis
XP_539439
275
31224
S135
G
V
K
S
A
Y
V
S
Y
D
V
Q
K
R
T
Cat
Felis silvestris
Mouse
Mus musculus
Q80X71
275
31154
S135
G
V
K
S
A
Y
V
S
Y
D
A
E
K
R
T
Rat
Rattus norvegicus
Q6AYA5
275
31134
S135
G
V
K
S
A
Y
V
S
Y
D
S
Q
K
R
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509431
275
30915
S135
G
V
K
S
A
Y
V
S
Y
D
Q
S
K
R
M
Chicken
Gallus gallus
NP_001012576
275
30931
N135
G
V
K
S
V
Y
V
N
Y
E
Q
S
R
R
I
Frog
Xenopus laevis
NP_001090222
271
30153
V132
V
G
V
K
S
V
L
V
N
Y
D
E
Q
K
Q
Zebra Danio
Brachydanio rerio
NP_001038517
267
29870
Y128
Y
V
G
V
K
S
V
Y
V
S
Y
D
Q
S
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
82.5
74.9
96
N.A.
95.6
94.9
N.A.
89
87.2
67.1
72.2
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
82.5
75.2
98.1
N.A.
97.8
96.7
N.A.
93.4
92.7
77.7
82.4
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
86.6
86.6
N.A.
80
53.3
0
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
93.3
86.6
N.A.
80
73.3
33.3
20
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
70
0
0
0
0
0
10
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
70
10
10
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
10
0
20
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
80
10
10
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% I
% Lys:
0
0
80
10
10
0
0
0
0
0
0
0
70
10
10
% K
% Leu:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
20
% M
% Asn:
0
0
0
0
0
0
0
10
10
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
20
50
20
0
10
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
10
80
0
% R
% Ser:
0
0
0
80
10
10
0
70
0
10
10
20
0
10
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
50
% T
% Val:
10
90
10
10
10
10
90
10
10
0
40
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
0
0
0
80
0
10
80
10
10
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _