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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMEM106B
All Species:
32.12
Human Site:
Y250
Identified Species:
78.52
UniProt:
Q9NUM4
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NUM4
NP_060844.2
274
31127
Y250
I
S
Q
E
R
Y
Q
Y
V
D
C
G
R
N
T
Chimpanzee
Pan troglodytes
XP_518973
332
37144
Y308
I
S
Q
E
R
Y
Q
Y
V
D
C
G
R
N
T
Rhesus Macaque
Macaca mulatta
XP_001082836
363
40099
Y339
I
S
Q
E
R
Y
Q
Y
V
D
C
G
R
N
T
Dog
Lupus familis
XP_539439
275
31224
Y251
I
S
Q
E
R
Y
Q
Y
V
D
C
G
R
N
T
Cat
Felis silvestris
Mouse
Mus musculus
Q80X71
275
31154
Y251
I
S
Q
E
R
Y
Q
Y
V
D
C
G
R
N
T
Rat
Rattus norvegicus
Q6AYA5
275
31134
Y251
I
S
Q
E
R
Y
Q
Y
V
D
C
G
R
N
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509431
275
30915
Y251
I
S
Q
E
R
Y
Q
Y
V
D
C
G
R
N
T
Chicken
Gallus gallus
NP_001012576
275
30931
Y251
I
S
R
E
K
Y
Q
Y
V
D
C
G
G
N
T
Frog
Xenopus laevis
NP_001090222
271
30153
Q248
Q
L
S
Q
E
V
Y
Q
Y
V
D
C
G
A
N
Zebra Danio
Brachydanio rerio
NP_001038517
267
29870
Y244
E
Q
V
S
Q
E
M
Y
Q
Y
V
D
C
G
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
82.5
74.9
96
N.A.
95.6
94.9
N.A.
89
87.2
67.1
72.2
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
82.5
75.2
98.1
N.A.
97.8
96.7
N.A.
93.4
92.7
77.7
82.4
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
80
0
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
93.3
6.6
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
80
10
10
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
80
10
10
0
0
0
% D
% Glu:
10
0
0
80
10
10
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
80
20
10
10
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
80
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
80
10
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
10
10
70
10
10
0
80
10
10
0
0
0
0
0
0
% Q
% Arg:
0
0
10
0
70
0
0
0
0
0
0
0
70
0
0
% R
% Ser:
0
80
10
10
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
80
% T
% Val:
0
0
10
0
0
10
0
0
80
10
10
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
80
10
90
10
10
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _