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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPTLC3
All Species:
30
Human Site:
S279
Identified Species:
55
UniProt:
Q9NUV7
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NUV7
NP_060797.2
552
62049
S279
F
K
H
N
N
T
Q
S
L
E
K
L
L
R
D
Chimpanzee
Pan troglodytes
XP_001135070
552
61957
S279
F
K
H
N
N
T
Q
S
L
E
K
L
L
R
D
Rhesus Macaque
Macaca mulatta
XP_001082737
552
62893
S279
F
K
H
N
N
T
Q
S
L
E
K
L
L
R
D
Dog
Lupus familis
XP_542889
552
61959
S279
F
K
H
N
N
M
Q
S
L
E
K
L
L
R
D
Cat
Felis silvestris
Mouse
Mus musculus
Q8BG54
563
63467
N279
F
K
H
N
N
A
E
N
L
E
K
L
L
R
E
Rat
Rattus norvegicus
NP_001099987
563
63673
N279
F
K
H
N
N
I
Q
N
L
E
K
L
L
R
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514082
550
62189
S277
F
K
H
N
N
M
Q
S
L
E
K
L
L
R
E
Chicken
Gallus gallus
XP_001231526
517
58495
S244
F
K
H
N
N
M
Q
S
L
E
K
L
L
R
D
Frog
Xenopus laevis
NP_001089928
550
61746
N277
F
K
H
N
N
M
Q
N
L
E
K
L
L
R
D
Zebra Danio
Brachydanio rerio
NP_001003562
553
62638
S280
F
K
H
N
N
M
Q
S
L
E
K
L
L
K
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784261
549
60922
S282
F
E
H
N
N
M
E
S
L
E
K
L
L
K
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40970
561
63092
G274
F
K
H
G
D
M
V
G
L
E
K
L
I
R
E
Red Bread Mold
Neurospora crassa
Q7RVY5
629
67428
I288
R
H
S
G
A
K
K
I
I
F
K
H
N
D
V
Conservation
Percent
Protein Identity:
100
99.6
91.4
90
N.A.
69.6
70.5
N.A.
83.1
73.3
73.3
69.6
N.A.
N.A.
N.A.
N.A.
54.8
Protein Similarity:
100
99.8
94.5
95.8
N.A.
81.7
82
N.A.
91.8
83.8
84.5
83.1
N.A.
N.A.
N.A.
N.A.
71.3
P-Site Identity:
100
100
100
93.3
N.A.
73.3
80
N.A.
86.6
93.3
86.6
80
N.A.
N.A.
N.A.
N.A.
66.6
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
93.3
93.3
93.3
93.3
N.A.
N.A.
N.A.
N.A.
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
41.5
24.8
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
60.6
40.3
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
53.3
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
73.3
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
8
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
8
0
0
0
0
0
0
0
0
8
47
% D
% Glu:
0
8
0
0
0
0
16
0
0
93
0
0
0
0
39
% E
% Phe:
93
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
0
0
0
16
0
0
0
8
0
0
0
0
0
0
0
% G
% His:
0
8
93
0
0
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
0
0
0
0
0
8
0
8
8
0
0
0
8
0
0
% I
% Lys:
0
85
0
0
0
8
8
0
0
0
100
0
0
16
0
% K
% Leu:
0
0
0
0
0
0
0
0
93
0
0
93
85
0
0
% L
% Met:
0
0
0
0
0
54
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
0
85
85
0
0
24
0
0
0
0
8
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
70
0
0
0
0
0
0
0
0
% Q
% Arg:
8
0
0
0
0
0
0
0
0
0
0
0
0
77
0
% R
% Ser:
0
0
8
0
0
0
0
62
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
24
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _