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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPTLC3
All Species:
18.18
Human Site:
T183
Identified Species:
33.33
UniProt:
Q9NUV7
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NUV7
NP_060797.2
552
62049
T183
K
Y
D
E
S
M
R
T
I
K
D
V
L
E
V
Chimpanzee
Pan troglodytes
XP_001135070
552
61957
T183
K
Y
D
E
S
M
R
T
I
K
D
V
L
E
V
Rhesus Macaque
Macaca mulatta
XP_001082737
552
62893
T183
K
Y
D
E
S
M
R
T
I
K
D
V
L
E
V
Dog
Lupus familis
XP_542889
552
61959
T183
S
Y
D
E
S
M
R
T
V
K
D
V
L
E
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8BG54
563
63467
R183
K
Y
D
D
S
M
V
R
V
K
D
T
L
E
K
Rat
Rattus norvegicus
NP_001099987
563
63673
K183
K
Y
N
E
S
M
E
K
V
K
D
T
I
E
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514082
550
62189
T181
A
N
S
Q
S
M
K
T
V
R
E
V
L
E
K
Chicken
Gallus gallus
XP_001231526
517
58495
R155
T
V
A
K
E
L
Q
R
Y
G
T
G
I
C
S
Frog
Xenopus laevis
NP_001089928
550
61746
L181
N
D
P
E
S
L
V
L
V
K
D
T
I
Q
S
Zebra Danio
Brachydanio rerio
NP_001003562
553
62638
T184
N
N
V
D
F
L
K
T
V
A
E
K
T
R
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784261
549
60922
V187
H
G
P
R
S
D
A
V
V
A
S
T
Q
Y
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40970
561
63092
A179
K
G
Q
C
T
D
A
A
L
E
S
V
D
K
Y
Red Bread Mold
Neurospora crassa
Q7RVY5
629
67428
A199
R
N
K
H
V
L
E
A
M
H
T
T
L
D
E
Conservation
Percent
Protein Identity:
100
99.6
91.4
90
N.A.
69.6
70.5
N.A.
83.1
73.3
73.3
69.6
N.A.
N.A.
N.A.
N.A.
54.8
Protein Similarity:
100
99.8
94.5
95.8
N.A.
81.7
82
N.A.
91.8
83.8
84.5
83.1
N.A.
N.A.
N.A.
N.A.
71.3
P-Site Identity:
100
100
100
80
N.A.
60
53.3
N.A.
40
0
26.6
6.6
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
86.6
N.A.
73.3
73.3
N.A.
73.3
26.6
53.3
40
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
41.5
24.8
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
60.6
40.3
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
0
0
0
16
16
0
16
0
0
0
0
0
% A
% Cys:
0
0
0
8
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
0
8
39
16
0
16
0
0
0
0
54
0
8
8
0
% D
% Glu:
0
0
0
47
8
0
16
0
0
8
16
0
0
54
16
% E
% Phe:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
16
0
0
0
0
0
0
0
8
0
8
0
0
0
% G
% His:
8
0
0
8
0
0
0
0
0
8
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
24
0
0
0
24
0
0
% I
% Lys:
47
0
8
8
0
0
16
8
0
54
0
8
0
8
24
% K
% Leu:
0
0
0
0
0
31
0
8
8
0
0
0
54
0
0
% L
% Met:
0
0
0
0
0
54
0
0
8
0
0
0
0
0
0
% M
% Asn:
16
24
8
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
16
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
8
8
0
0
8
0
0
0
0
0
8
8
8
% Q
% Arg:
8
0
0
8
0
0
31
16
0
8
0
0
0
8
0
% R
% Ser:
8
0
8
0
70
0
0
0
0
0
16
0
0
0
16
% S
% Thr:
8
0
0
0
8
0
0
47
0
0
16
39
8
0
0
% T
% Val:
0
8
8
0
8
0
16
8
54
0
0
47
0
0
24
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
47
0
0
0
0
0
0
8
0
0
0
0
8
16
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _