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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPTLC3
All Species:
35.76
Human Site:
T295
Identified Species:
65.56
UniProt:
Q9NUV7
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NUV7
NP_060797.2
552
62049
T295
V
I
Y
G
Q
P
R
T
R
R
A
W
K
K
I
Chimpanzee
Pan troglodytes
XP_001135070
552
61957
T295
V
I
Y
G
Q
P
R
T
R
R
A
W
K
K
I
Rhesus Macaque
Macaca mulatta
XP_001082737
552
62893
T295
V
I
Y
G
Q
P
R
T
R
R
A
W
K
K
I
Dog
Lupus familis
XP_542889
552
61959
V295
V
I
Y
G
Q
P
R
V
R
R
A
W
K
K
I
Cat
Felis silvestris
Mouse
Mus musculus
Q8BG54
563
63467
T295
I
I
R
G
Q
P
G
T
G
R
A
W
K
K
I
Rat
Rattus norvegicus
NP_001099987
563
63673
T295
I
I
R
G
Q
P
R
T
G
R
A
W
K
K
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514082
550
62189
R293
V
I
Y
G
Q
P
R
R
R
R
A
W
K
K
I
Chicken
Gallus gallus
XP_001231526
517
58495
S260
I
V
Y
G
Q
P
R
S
R
R
A
W
R
K
I
Frog
Xenopus laevis
NP_001089928
550
61746
T293
V
V
N
G
Q
P
R
T
H
R
A
W
K
K
I
Zebra Danio
Brachydanio rerio
NP_001003562
553
62638
T296
I
C
S
G
Q
P
R
T
H
R
S
W
K
K
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784261
549
60922
T298
I
A
E
G
Q
P
R
T
H
R
P
W
K
K
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40970
561
63092
T290
I
V
L
G
Q
P
K
T
N
R
P
W
K
K
I
Red Bread Mold
Neurospora crassa
Q7RVY5
629
67428
A304
D
L
E
K
K
L
A
A
L
P
L
H
I
P
K
Conservation
Percent
Protein Identity:
100
99.6
91.4
90
N.A.
69.6
70.5
N.A.
83.1
73.3
73.3
69.6
N.A.
N.A.
N.A.
N.A.
54.8
Protein Similarity:
100
99.8
94.5
95.8
N.A.
81.7
82
N.A.
91.8
83.8
84.5
83.1
N.A.
N.A.
N.A.
N.A.
71.3
P-Site Identity:
100
100
100
93.3
N.A.
73.3
80
N.A.
93.3
73.3
80
66.6
N.A.
N.A.
N.A.
N.A.
66.6
P-Site Similarity:
100
100
100
93.3
N.A.
80
86.6
N.A.
93.3
100
86.6
80
N.A.
N.A.
N.A.
N.A.
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
41.5
24.8
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
60.6
40.3
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
60
0
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
80
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
0
8
8
0
0
70
0
0
0
0
% A
% Cys:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
16
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
93
0
0
8
0
16
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
24
0
0
8
0
0
0
% H
% Ile:
47
54
0
0
0
0
0
0
0
0
0
0
8
0
93
% I
% Lys:
0
0
0
8
8
0
8
0
0
0
0
0
85
93
8
% K
% Leu:
0
8
8
0
0
8
0
0
8
0
8
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
0
0
0
0
0
8
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
93
0
0
0
8
16
0
0
8
0
% P
% Gln:
0
0
0
0
93
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
16
0
0
0
77
8
47
93
0
0
8
0
0
% R
% Ser:
0
0
8
0
0
0
0
8
0
0
8
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
70
0
0
0
0
0
0
0
% T
% Val:
47
24
0
0
0
0
0
8
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
93
0
0
0
% W
% Tyr:
0
0
47
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _