KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPTLC3
All Species:
33.94
Human Site:
Y531
Identified Species:
62.22
UniProt:
Q9NUV7
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NUV7
NP_060797.2
552
62049
Y531
G
D
L
L
Q
L
K
Y
S
R
H
K
K
S
A
Chimpanzee
Pan troglodytes
XP_001135070
552
61957
Y531
G
D
L
L
Q
L
K
Y
S
R
H
K
K
S
A
Rhesus Macaque
Macaca mulatta
XP_001082737
552
62893
Y531
G
D
L
L
Q
L
K
Y
S
R
H
K
K
S
A
Dog
Lupus familis
XP_542889
552
61959
Y531
G
D
L
L
Q
L
K
Y
S
R
H
R
K
S
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8BG54
563
63467
Y531
G
D
L
L
N
V
K
Y
F
P
L
K
K
S
G
Rat
Rattus norvegicus
NP_001099987
563
63673
Y531
G
D
L
L
N
V
K
Y
F
P
Y
K
K
S
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514082
550
62189
Y529
G
D
L
L
Q
L
K
Y
S
R
H
K
K
S
V
Chicken
Gallus gallus
XP_001231526
517
58495
Y496
G
D
F
L
H
L
K
Y
S
R
Y
S
K
S
S
Frog
Xenopus laevis
NP_001089928
550
61746
Y529
G
E
F
L
Q
L
K
Y
S
R
L
S
R
S
A
Zebra Danio
Brachydanio rerio
NP_001003562
553
62638
F532
G
D
Y
I
R
V
K
F
S
R
H
R
R
P
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784261
549
60922
E528
K
I
M
D
E
V
G
E
E
L
G
V
K
Y
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40970
561
63092
S526
G
D
K
L
N
L
K
S
N
S
G
K
S
S
Y
Red Bread Mold
Neurospora crassa
Q7RVY5
629
67428
A588
V
A
E
L
R
A
Q
A
S
D
E
K
K
G
V
Conservation
Percent
Protein Identity:
100
99.6
91.4
90
N.A.
69.6
70.5
N.A.
83.1
73.3
73.3
69.6
N.A.
N.A.
N.A.
N.A.
54.8
Protein Similarity:
100
99.8
94.5
95.8
N.A.
81.7
82
N.A.
91.8
83.8
84.5
83.1
N.A.
N.A.
N.A.
N.A.
71.3
P-Site Identity:
100
100
100
93.3
N.A.
60
60
N.A.
93.3
66.6
66.6
40
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
66.6
73.3
N.A.
93.3
80
80
80
N.A.
N.A.
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
41.5
24.8
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
60.6
40.3
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
46.6
26.6
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
53.3
40
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
8
0
8
0
0
0
0
0
0
39
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
77
0
8
0
0
0
0
0
8
0
0
0
0
0
% D
% Glu:
0
8
8
0
8
0
0
8
8
0
8
0
0
0
0
% E
% Phe:
0
0
16
0
0
0
0
8
16
0
0
0
0
0
0
% F
% Gly:
85
0
0
0
0
0
8
0
0
0
16
0
0
8
16
% G
% His:
0
0
0
0
8
0
0
0
0
0
47
0
0
0
0
% H
% Ile:
0
8
0
8
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
8
0
8
0
0
0
85
0
0
0
0
62
77
0
0
% K
% Leu:
0
0
54
85
0
62
0
0
0
8
16
0
0
0
0
% L
% Met:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
24
0
0
0
8
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
16
0
0
0
8
0
% P
% Gln:
0
0
0
0
47
0
8
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
16
0
0
0
0
62
0
16
16
0
0
% R
% Ser:
0
0
0
0
0
0
0
8
70
8
0
16
8
77
16
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
8
0
0
0
0
31
0
0
0
0
0
8
0
0
16
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
70
0
0
16
0
0
8
16
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _