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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TDP1
All Species:
16.67
Human Site:
S391
Identified Species:
30.56
UniProt:
Q9NUW8
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NUW8
NP_001008744.1
608
68420
S391
S
S
M
P
N
A
E
S
W
P
V
V
G
Q
F
Chimpanzee
Pan troglodytes
XP_510113
677
75678
S460
S
S
M
P
N
A
E
S
W
P
V
V
G
Q
F
Rhesus Macaque
Macaca mulatta
XP_001089545
603
68022
S386
S
S
I
P
N
A
E
S
W
P
V
V
G
Q
F
Dog
Lupus familis
XP_547950
609
68466
S392
S
S
I
T
K
G
E
S
W
P
I
V
G
Q
F
Cat
Felis silvestris
Mouse
Mus musculus
Q8BJ37
609
68671
C392
P
S
T
P
K
G
E
C
W
P
I
V
G
Q
F
Rat
Rattus norvegicus
Q4G056
609
68614
C392
P
S
A
P
R
G
E
C
W
P
V
V
G
Q
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_421313
606
67931
S387
S
S
I
P
A
Q
E
S
W
P
V
V
G
Q
F
Frog
Xenopus laevis
NP_001087094
597
67899
M380
S
A
G
P
D
K
E
M
W
P
V
I
G
Q
F
Zebra Danio
Brachydanio rerio
XP_700174
615
70098
R399
Q
P
M
Q
N
E
E
R
W
H
V
L
G
Q
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VQM4
580
64175
L364
H
P
W
G
H
A
R
L
A
S
L
L
A
K
H
Honey Bee
Apis mellifera
XP_392205
692
79662
L460
S
S
V
N
V
F
F
L
A
S
V
P
G
R
H
Nematode Worm
Caenorhab. elegans
Q9TXV7
451
51040
H235
P
P
T
Q
R
P
G
H
P
R
L
F
R
I
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001169273
665
74475
I424
L
R
N
V
L
D
E
I
M
F
N
K
Q
F
C
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.9
96.5
86.8
N.A.
81.2
81.9
N.A.
N.A.
69.7
66.1
54.1
N.A.
32.4
30
29.1
N.A.
Protein Similarity:
100
87.1
98.1
92.2
N.A.
88.5
88.5
N.A.
N.A.
80.9
79.4
69.9
N.A.
50
45.6
42.9
N.A.
P-Site Identity:
100
100
93.3
66.6
N.A.
60
66.6
N.A.
N.A.
80
60
53.3
N.A.
6.6
26.6
0
N.A.
P-Site Similarity:
100
100
100
80
N.A.
66.6
66.6
N.A.
N.A.
86.6
80
60
N.A.
33.3
40
6.6
N.A.
Percent
Protein Identity:
N.A.
32
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
47.8
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
0
8
31
0
0
16
0
0
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
16
0
0
0
0
0
0
8
% C
% Asp:
0
0
0
0
8
8
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
8
77
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
8
8
0
0
8
0
8
0
8
70
% F
% Gly:
0
0
8
8
0
24
8
0
0
0
0
0
77
0
0
% G
% His:
8
0
0
0
8
0
0
8
0
8
0
0
0
0
16
% H
% Ile:
0
0
24
0
0
0
0
8
0
0
16
8
0
8
0
% I
% Lys:
0
0
0
0
16
8
0
0
0
0
0
8
0
8
0
% K
% Leu:
8
0
0
0
8
0
0
16
0
0
16
16
0
0
8
% L
% Met:
0
0
24
0
0
0
0
8
8
0
0
0
0
0
0
% M
% Asn:
0
0
8
8
31
0
0
0
0
0
8
0
0
0
0
% N
% Pro:
24
24
0
54
0
8
0
0
8
62
0
8
0
0
0
% P
% Gln:
8
0
0
16
0
8
0
0
0
0
0
0
8
70
0
% Q
% Arg:
0
8
0
0
16
0
8
8
0
8
0
0
8
8
0
% R
% Ser:
54
62
0
0
0
0
0
39
0
16
0
0
0
0
0
% S
% Thr:
0
0
16
8
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
8
8
8
0
0
0
0
0
62
54
0
0
0
% V
% Trp:
0
0
8
0
0
0
0
0
70
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _