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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TDP1
All Species:
21.82
Human Site:
S563
Identified Species:
40
UniProt:
Q9NUW8
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NUW8
NP_001008744.1
608
68420
S563
K
Q
K
F
F
A
G
S
Q
E
P
M
A
T
F
Chimpanzee
Pan troglodytes
XP_510113
677
75678
S632
K
Q
K
F
F
A
G
S
Q
E
P
M
A
T
F
Rhesus Macaque
Macaca mulatta
XP_001089545
603
68022
S558
K
Q
K
F
F
A
G
S
Q
E
P
M
A
T
F
Dog
Lupus familis
XP_547950
609
68466
S564
K
Q
K
F
F
S
G
S
K
E
P
A
A
A
F
Cat
Felis silvestris
Mouse
Mus musculus
Q8BJ37
609
68671
S564
K
Q
K
F
F
S
S
S
C
E
P
T
A
S
F
Rat
Rattus norvegicus
Q4G056
609
68614
S564
K
Q
K
F
F
S
S
S
S
E
P
M
A
S
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_421313
606
67931
S559
H
V
K
G
N
M
L
S
E
G
K
D
S
A
T
Frog
Xenopus laevis
NP_001087094
597
67899
N552
K
V
N
I
Y
S
H
N
E
P
S
G
N
A
F
Zebra Danio
Brachydanio rerio
XP_700174
615
70098
C571
E
K
N
V
F
P
A
C
S
S
S
I
G
F
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VQM4
580
64175
F536
G
V
L
F
L
P
R
F
V
T
G
E
D
T
F
Honey Bee
Apis mellifera
XP_392205
692
79662
H632
G
T
V
G
K
N
S
H
Y
I
M
N
Y
E
G
Nematode Worm
Caenorhab. elegans
Q9TXV7
451
51040
L407
R
S
W
E
M
G
V
L
I
T
D
P
S
R
F
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001169273
665
74475
I596
C
T
E
K
S
R
S
I
R
D
G
V
A
L
G
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.9
96.5
86.8
N.A.
81.2
81.9
N.A.
N.A.
69.7
66.1
54.1
N.A.
32.4
30
29.1
N.A.
Protein Similarity:
100
87.1
98.1
92.2
N.A.
88.5
88.5
N.A.
N.A.
80.9
79.4
69.9
N.A.
50
45.6
42.9
N.A.
P-Site Identity:
100
100
100
73.3
N.A.
66.6
73.3
N.A.
N.A.
13.3
13.3
6.6
N.A.
20
0
6.6
N.A.
P-Site Similarity:
100
100
100
86.6
N.A.
80
86.6
N.A.
N.A.
26.6
40
26.6
N.A.
20
0
20
N.A.
Percent
Protein Identity:
N.A.
32
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
47.8
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
33.3
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
24
8
0
0
0
0
8
54
24
0
% A
% Cys:
8
0
0
0
0
0
0
8
8
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
8
8
8
8
0
0
% D
% Glu:
8
0
8
8
0
0
0
0
16
47
0
8
0
8
0
% E
% Phe:
0
0
0
54
54
0
0
8
0
0
0
0
0
8
70
% F
% Gly:
16
0
0
16
0
8
31
0
0
8
16
8
8
0
16
% G
% His:
8
0
0
0
0
0
8
8
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
8
0
0
0
8
8
8
0
8
0
0
0
% I
% Lys:
54
8
54
8
8
0
0
0
8
0
8
0
0
0
0
% K
% Leu:
0
0
8
0
8
0
8
8
0
0
0
0
0
8
0
% L
% Met:
0
0
0
0
8
8
0
0
0
0
8
31
0
0
0
% M
% Asn:
0
0
16
0
8
8
0
8
0
0
0
8
8
0
0
% N
% Pro:
0
0
0
0
0
16
0
0
0
8
47
8
0
0
8
% P
% Gln:
0
47
0
0
0
0
0
0
24
0
0
0
0
0
0
% Q
% Arg:
8
0
0
0
0
8
8
0
8
0
0
0
0
8
0
% R
% Ser:
0
8
0
0
8
31
31
54
16
8
16
0
16
16
0
% S
% Thr:
0
16
0
0
0
0
0
0
0
16
0
8
0
31
8
% T
% Val:
0
24
8
8
0
0
8
0
8
0
0
8
0
0
0
% V
% Trp:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
0
8
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _