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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TDP1
All Species:
33.64
Human Site:
Y178
Identified Species:
61.67
UniProt:
Q9NUW8
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NUW8
NP_001008744.1
608
68420
Y178
V
S
G
V
K
P
K
Y
N
S
G
A
L
H
I
Chimpanzee
Pan troglodytes
XP_510113
677
75678
Y247
V
S
G
V
K
P
K
Y
N
S
G
A
L
H
I
Rhesus Macaque
Macaca mulatta
XP_001089545
603
68022
Y173
V
S
G
V
K
P
K
Y
N
S
G
A
L
H
I
Dog
Lupus familis
XP_547950
609
68466
Y179
V
S
G
I
K
P
K
Y
N
S
G
A
L
H
I
Cat
Felis silvestris
Mouse
Mus musculus
Q8BJ37
609
68671
Y179
V
S
G
I
K
A
K
Y
N
S
K
A
L
H
I
Rat
Rattus norvegicus
Q4G056
609
68614
Y179
V
S
G
I
K
A
K
Y
N
S
K
A
L
H
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_421313
606
67931
Y173
V
R
G
I
E
Q
S
Y
N
S
G
A
L
H
I
Frog
Xenopus laevis
NP_001087094
597
67899
Y166
V
T
G
I
K
P
K
Y
N
S
G
A
L
H
I
Zebra Danio
Brachydanio rerio
XP_700174
615
70098
Y185
V
T
G
I
P
K
K
Y
N
T
G
A
L
H
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VQM4
580
64175
K161
L
T
A
I
T
D
S
K
P
T
H
S
E
P
L
Honey Bee
Apis mellifera
XP_392205
692
79662
E212
S
K
H
A
E
M
D
E
K
Y
D
Y
R
N
S
Nematode Worm
Caenorhab. elegans
Q9TXV7
451
51040
I41
G
S
I
Y
F
T
P
I
G
G
I
S
V
P
R
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001169273
665
74475
P216
L
M
H
V
Q
G
L
P
S
W
T
N
T
S
S
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.9
96.5
86.8
N.A.
81.2
81.9
N.A.
N.A.
69.7
66.1
54.1
N.A.
32.4
30
29.1
N.A.
Protein Similarity:
100
87.1
98.1
92.2
N.A.
88.5
88.5
N.A.
N.A.
80.9
79.4
69.9
N.A.
50
45.6
42.9
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
80
80
N.A.
N.A.
66.6
86.6
66.6
N.A.
0
0
6.6
N.A.
P-Site Similarity:
100
100
100
100
N.A.
86.6
86.6
N.A.
N.A.
80
100
86.6
N.A.
40
13.3
20
N.A.
Percent
Protein Identity:
N.A.
32
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
47.8
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
0
16
0
0
0
0
0
70
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
8
8
0
0
0
8
0
0
0
0
% D
% Glu:
0
0
0
0
16
0
0
8
0
0
0
0
8
0
0
% E
% Phe:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
70
0
0
8
0
0
8
8
54
0
0
0
0
% G
% His:
0
0
16
0
0
0
0
0
0
0
8
0
0
70
0
% H
% Ile:
0
0
8
54
0
0
0
8
0
0
8
0
0
0
70
% I
% Lys:
0
8
0
0
54
8
62
8
8
0
16
0
0
0
0
% K
% Leu:
16
0
0
0
0
0
8
0
0
0
0
0
70
0
8
% L
% Met:
0
8
0
0
0
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
70
0
0
8
0
8
0
% N
% Pro:
0
0
0
0
8
39
8
8
8
0
0
0
0
16
0
% P
% Gln:
0
0
0
0
8
8
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
8
0
0
0
0
0
0
0
0
0
0
8
0
8
% R
% Ser:
8
54
0
0
0
0
16
0
8
62
0
16
0
8
16
% S
% Thr:
0
24
0
0
8
8
0
0
0
16
8
0
8
0
0
% T
% Val:
70
0
0
31
0
0
0
0
0
0
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
70
0
8
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _