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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TDP1
All Species:
30.3
Human Site:
Y245
Identified Species:
55.56
UniProt:
Q9NUW8
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NUW8
NP_001008744.1
608
68420
Y245
L
H
A
Q
A
K
P
Y
E
N
I
S
L
C
Q
Chimpanzee
Pan troglodytes
XP_510113
677
75678
Y314
L
H
A
Q
A
K
P
Y
E
N
I
S
L
C
Q
Rhesus Macaque
Macaca mulatta
XP_001089545
603
68022
Y240
L
H
A
Q
A
K
P
Y
E
N
I
S
L
C
Q
Dog
Lupus familis
XP_547950
609
68466
Y246
L
H
A
Q
A
K
P
Y
E
N
I
S
L
C
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q8BJ37
609
68671
Y246
L
H
A
Q
A
K
P
Y
A
N
I
S
L
C
Q
Rat
Rattus norvegicus
Q4G056
609
68614
Y246
L
H
A
Q
A
K
P
Y
A
N
I
S
L
C
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_421313
606
67931
F240
L
L
A
Q
A
R
P
F
E
N
I
S
F
C
Q
Frog
Xenopus laevis
NP_001087094
597
67899
Y233
L
H
E
D
A
H
P
Y
E
H
I
R
L
C
Q
Zebra Danio
Brachydanio rerio
XP_700174
615
70098
Y252
L
I
E
Q
A
K
P
Y
P
H
I
S
F
C
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VQM4
580
64175
L215
L
D
K
P
L
L
L
L
Y
G
D
E
S
P
E
Honey Bee
Apis mellifera
XP_392205
692
79662
Y273
K
Y
A
C
S
A
P
Y
H
I
F
F
S
T
V
Nematode Worm
Caenorhab. elegans
Q9TXV7
451
51040
P93
P
P
S
L
R
E
Y
P
I
T
L
V
V
G
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001169273
665
74475
P281
E
L
M
K
K
L
K
P
A
N
W
I
L
H
R
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.9
96.5
86.8
N.A.
81.2
81.9
N.A.
N.A.
69.7
66.1
54.1
N.A.
32.4
30
29.1
N.A.
Protein Similarity:
100
87.1
98.1
92.2
N.A.
88.5
88.5
N.A.
N.A.
80.9
79.4
69.9
N.A.
50
45.6
42.9
N.A.
P-Site Identity:
100
100
100
100
N.A.
93.3
93.3
N.A.
N.A.
73.3
66.6
66.6
N.A.
6.6
20
0
N.A.
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
N.A.
86.6
73.3
73.3
N.A.
13.3
33.3
26.6
N.A.
Percent
Protein Identity:
N.A.
32
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
47.8
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
62
0
70
8
0
0
24
0
0
0
0
0
8
% A
% Cys:
0
0
0
8
0
0
0
0
0
0
0
0
0
70
0
% C
% Asp:
0
8
0
8
0
0
0
0
0
0
8
0
0
0
0
% D
% Glu:
8
0
16
0
0
8
0
0
47
0
0
8
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
8
8
16
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
8
0
0
0
8
0
% G
% His:
0
54
0
0
0
8
0
0
8
16
0
0
0
8
0
% H
% Ile:
0
8
0
0
0
0
0
0
8
8
70
8
0
0
0
% I
% Lys:
8
0
8
8
8
54
8
0
0
0
0
0
0
0
0
% K
% Leu:
77
16
0
8
8
16
8
8
0
0
8
0
62
0
0
% L
% Met:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
62
0
0
0
0
0
% N
% Pro:
8
8
0
8
0
0
77
16
8
0
0
0
0
8
0
% P
% Gln:
0
0
0
62
0
0
0
0
0
0
0
0
0
0
70
% Q
% Arg:
0
0
0
0
8
8
0
0
0
0
0
8
0
0
8
% R
% Ser:
0
0
8
0
8
0
0
0
0
0
0
62
16
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
8
0
0
0
8
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
8
8
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
8
70
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _