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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NUDT15
All Species:
13.64
Human Site:
S107
Identified Species:
37.5
UniProt:
Q9NV35
Number Species:
8
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NV35
NP_060753.1
164
18609
S107
E
V
D
V
T
H
D
S
E
P
K
N
V
E
P
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8BG93
170
19558
S106
E
V
D
M
T
H
D
S
E
P
R
N
M
E
P
Rat
Rattus norvegicus
NP_001099519
170
19666
S106
E
V
D
V
T
H
E
S
E
P
R
N
M
E
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514152
265
29238
S208
E
V
D
V
T
H
E
S
E
P
Q
N
V
E
P
Chicken
Gallus gallus
XP_417053
245
27301
P188
E
A
E
P
G
E
E
P
R
N
C
E
P
D
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001330868
155
17624
A110
E
M
D
R
S
Y
S
A
E
A
V
N
L
E
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782891
150
16789
F105
R
G
E
V
D
A
D
F
K
K
D
P
E
N
T
Poplar Tree
Populus trichocarpa
XP_002311425
147
16555
E103
R
A
N
L
A
D
P
E
Q
V
P
Q
N
L
E
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9CA40
147
16338
P103
L
V
D
P
S
Q
E
P
K
N
M
E
P
E
K
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
N.A.
N.A.
85.8
83.5
N.A.
44.5
46.5
N.A.
53.6
N.A.
N.A.
N.A.
N.A.
54.2
Protein Similarity:
100
N.A.
N.A.
N.A.
N.A.
90.5
88.8
N.A.
52
53.4
N.A.
71.3
N.A.
N.A.
N.A.
N.A.
68.2
P-Site Identity:
100
N.A.
N.A.
N.A.
N.A.
80
80
N.A.
86.6
6.6
N.A.
40
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
N.A.
N.A.
N.A.
N.A.
100
100
N.A.
100
26.6
N.A.
73.3
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
37.8
N.A.
N.A.
39.6
N.A.
N.A.
Protein Similarity:
53
N.A.
N.A.
55.4
N.A.
N.A.
P-Site Identity:
0
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
20
N.A.
N.A.
40
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
23
0
0
12
12
0
12
0
12
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
12
0
0
0
0
% C
% Asp:
0
0
67
0
12
12
34
0
0
0
12
0
0
12
0
% D
% Glu:
67
0
23
0
0
12
45
12
56
0
0
23
12
67
12
% E
% Phe:
0
0
0
0
0
0
0
12
0
0
0
0
0
0
0
% F
% Gly:
0
12
0
0
12
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
45
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
23
12
12
0
0
0
23
% K
% Leu:
12
0
0
12
0
0
0
0
0
0
0
0
12
12
0
% L
% Met:
0
12
0
12
0
0
0
0
0
0
12
0
23
0
0
% M
% Asn:
0
0
12
0
0
0
0
0
0
23
0
56
12
12
0
% N
% Pro:
0
0
0
23
0
0
12
23
0
45
12
12
23
0
56
% P
% Gln:
0
0
0
0
0
12
0
0
12
0
12
12
0
0
0
% Q
% Arg:
23
0
0
12
0
0
0
0
12
0
23
0
0
0
0
% R
% Ser:
0
0
0
0
23
0
12
45
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
45
0
0
0
0
0
0
0
0
0
12
% T
% Val:
0
56
0
45
0
0
0
0
0
12
12
0
23
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
12
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _