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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NUDT15
All Species:
20.61
Human Site:
Y92
Identified Species:
56.67
UniProt:
Q9NV35
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NV35
NP_060753.1
164
18609
Y92
I
E
K
E
N
Y
H
Y
V
T
I
L
M
K
G
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8BG93
170
19558
Y91
V
E
K
E
N
Y
H
Y
V
T
I
L
M
K
G
Rat
Rattus norvegicus
NP_001099519
170
19666
Y91
V
E
K
E
N
Y
H
Y
V
T
I
L
M
K
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514152
265
29238
Y193
S
V
K
D
S
Y
H
Y
V
T
I
L
M
K
G
Chicken
Gallus gallus
XP_417053
245
27301
Y173
C
A
A
E
R
Y
H
Y
V
T
V
L
M
K
G
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001330868
155
17624
Y95
K
L
E
E
N
Y
H
Y
I
T
I
F
M
L
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782891
150
16789
Y90
A
V
C
I
E
K
D
Y
H
Y
V
T
I
F
M
Poplar Tree
Populus trichocarpa
XP_002311425
147
16555
C88
F
L
E
E
P
K
P
C
H
Y
V
T
V
F
L
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9CA40
147
16338
V88
A
P
T
P
S
H
Y
V
S
V
S
I
R
A
V
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
N.A.
N.A.
85.8
83.5
N.A.
44.5
46.5
N.A.
53.6
N.A.
N.A.
N.A.
N.A.
54.2
Protein Similarity:
100
N.A.
N.A.
N.A.
N.A.
90.5
88.8
N.A.
52
53.4
N.A.
71.3
N.A.
N.A.
N.A.
N.A.
68.2
P-Site Identity:
100
N.A.
N.A.
N.A.
N.A.
93.3
93.3
N.A.
73.3
66.6
N.A.
60
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
N.A.
N.A.
N.A.
N.A.
100
100
N.A.
86.6
73.3
N.A.
73.3
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
37.8
N.A.
N.A.
39.6
N.A.
N.A.
Protein Similarity:
53
N.A.
N.A.
55.4
N.A.
N.A.
P-Site Identity:
6.6
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
23
12
12
0
0
0
0
0
0
0
0
0
0
12
0
% A
% Cys:
12
0
12
0
0
0
0
12
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
12
0
0
12
0
0
0
0
0
0
0
0
% D
% Glu:
0
34
23
67
12
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
12
0
0
0
0
0
0
0
0
0
0
12
0
23
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
67
% G
% His:
0
0
0
0
0
12
67
0
23
0
0
0
0
0
0
% H
% Ile:
12
0
0
12
0
0
0
0
12
0
56
12
12
0
0
% I
% Lys:
12
0
45
0
0
23
0
0
0
0
0
0
0
56
0
% K
% Leu:
0
23
0
0
0
0
0
0
0
0
0
56
0
12
12
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
67
0
12
% M
% Asn:
0
0
0
0
45
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
12
0
12
12
0
12
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
12
0
0
0
0
0
0
0
12
0
0
% R
% Ser:
12
0
0
0
23
0
0
0
12
0
12
0
0
0
0
% S
% Thr:
0
0
12
0
0
0
0
0
0
67
0
23
0
0
0
% T
% Val:
23
23
0
0
0
0
0
12
56
12
34
0
12
0
12
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
67
12
78
0
23
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _