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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FANCI All Species: 6.97
Human Site: S1222 Identified Species: 11.79
UniProt: Q9NVI1 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NVI1 NP_001106849.1 1328 149324 S1222 Y V Q N K S K S L N Y T G E K
Chimpanzee Pan troglodytes XP_001166960 1328 149462 S1222 Y V Q N K S K S L N Y T G E K
Rhesus Macaque Macaca mulatta XP_001092590 1268 142835 R1182 T V A T A M A R V L R E T K P
Dog Lupus familis XP_545849 1234 138558 E1148 A M A R V L R E T K P I P N L
Cat Felis silvestris
Mouse Mus musculus Q8K368 1330 149307 D1223 Y V Q N K S S D A P K C S E K
Rat Rattus norvegicus XP_001064803 1332 149518 N1225 Y V Q N K S S N N P K C P E K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513065 736 82976 V650 A A V A P A K V F Q K A K P I
Chicken Gallus gallus NP_001108323 1338 149271 E1225 S E S L S F A E E K K K K K K
Frog Xenopus laevis NP_001164682 1337 149488 S1228 N I H S E S L S L A A E K K K
Zebra Danio Brachydanio rerio XP_001921139 1367 152995 E1218 T Y V Q V X S E K L K K K K K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001122372 706 81709 C620 P P V K L E L C T D I H G I D
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001190805 989 110178 K903 T Q R E D T E K A I C N Q L G
Poplar Tree Populus trichocarpa XP_002315511 1406 157649 N1253 Q L T V P L Y N F V A E M Q R
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_001119400 1470 164337 L1293 Q K R E V L L L F Q I Q E Q Q
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 93 81.4 N.A. 80.8 81.3 N.A. 39.7 66.9 66.9 59.4 N.A. N.A. 20.4 N.A. 33.3
Protein Similarity: 100 99.6 94.2 86.5 N.A. 89.6 89.8 N.A. 46.9 81.6 81.5 75.9 N.A. N.A. 33 N.A. 49.4
P-Site Identity: 100 100 6.6 0 N.A. 53.3 53.3 N.A. 6.6 6.6 26.6 6.6 N.A. N.A. 6.6 N.A. 0
P-Site Similarity: 100 100 20 13.3 N.A. 53.3 60 N.A. 13.3 13.3 53.3 13.3 N.A. N.A. 13.3 N.A. 20
Percent
Protein Identity: 22.7 N.A. N.A. 23.4 N.A. N.A.
Protein Similarity: 44.1 N.A. N.A. 43 N.A. N.A.
P-Site Identity: 0 N.A. N.A. 0 N.A. N.A.
P-Site Similarity: 26.6 N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 15 8 15 8 8 8 15 0 15 8 15 8 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 8 0 0 8 15 0 0 0 % C
% Asp: 0 0 0 0 8 0 0 8 0 8 0 0 0 0 8 % D
% Glu: 0 8 0 15 8 8 8 22 8 0 0 22 8 29 0 % E
% Phe: 0 0 0 0 0 8 0 0 22 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 22 0 8 % G
% His: 0 0 8 0 0 0 0 0 0 0 0 8 0 0 0 % H
% Ile: 0 8 0 0 0 0 0 0 0 8 15 8 0 8 8 % I
% Lys: 0 8 0 8 29 0 22 8 8 15 36 15 29 29 50 % K
% Leu: 0 8 0 8 8 22 22 8 22 15 0 0 0 8 8 % L
% Met: 0 8 0 0 0 8 0 0 0 0 0 0 8 0 0 % M
% Asn: 8 0 0 29 0 0 0 15 8 15 0 8 0 8 0 % N
% Pro: 8 8 0 0 15 0 0 0 0 15 8 0 15 8 8 % P
% Gln: 15 8 29 8 0 0 0 0 0 15 0 8 8 15 8 % Q
% Arg: 0 0 15 8 0 0 8 8 0 0 8 0 0 0 8 % R
% Ser: 8 0 8 8 8 36 22 22 0 0 0 0 8 0 0 % S
% Thr: 22 0 8 8 0 8 0 0 15 0 0 15 8 0 0 % T
% Val: 0 36 22 8 22 0 0 8 8 8 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 29 8 0 0 0 0 8 0 0 0 15 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _