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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FANCI All Species: 7.88
Human Site: S659 Identified Species: 13.33
UniProt: Q9NVI1 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NVI1 NP_001106849.1 1328 149324 S659 L T Q G D K I S L Q E P L D Y
Chimpanzee Pan troglodytes XP_001166960 1328 149462 S659 L T Q G D K I S L Q E P L D Y
Rhesus Macaque Macaca mulatta XP_001092590 1268 142835 P637 Q L K Q F Y E P K P D L L P P
Dog Lupus familis XP_545849 1234 138558 K603 Q T L L S Q L K Q F Y E P E P
Cat Felis silvestris
Mouse Mus musculus Q8K368 1330 149307 F658 L T Q G S Q I F L Q E P L D H
Rat Rattus norvegicus XP_001064803 1332 149518 F658 L T Q G S Q T F L Q E P L G H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513065 736 82976 E105 Q H P L Q H E E D E E G G L Q
Chicken Gallus gallus NP_001108323 1338 149271 F661 M A Q G D Q I F L Q E P L A H
Frog Xenopus laevis NP_001164682 1337 149488 F660 T A Q G D H I F L Q E P L A H
Zebra Danio Brachydanio rerio XP_001921139 1367 152995 F659 S A Q G D Q V F L Q E P L A H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001122372 706 81709 R75 W I I A D F P R Y S K Q H L V
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001190805 989 110178 R358 L T Q Q A D I R L V L Y E G L
Poplar Tree Populus trichocarpa XP_002315511 1406 157649 V651 K S L S G N V V I E E P L D A
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_001119400 1470 164337 T652 R V E G D K F T I E E P L D R
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 93 81.4 N.A. 80.8 81.3 N.A. 39.7 66.9 66.9 59.4 N.A. N.A. 20.4 N.A. 33.3
Protein Similarity: 100 99.6 94.2 86.5 N.A. 89.6 89.8 N.A. 46.9 81.6 81.5 75.9 N.A. N.A. 33 N.A. 49.4
P-Site Identity: 100 100 6.6 6.6 N.A. 73.3 60 N.A. 6.6 60 60 53.3 N.A. N.A. 6.6 N.A. 33.3
P-Site Similarity: 100 100 20 26.6 N.A. 86.6 73.3 N.A. 13.3 80 66.6 73.3 N.A. N.A. 13.3 N.A. 33.3
Percent
Protein Identity: 22.7 N.A. N.A. 23.4 N.A. N.A.
Protein Similarity: 44.1 N.A. N.A. 43 N.A. N.A.
P-Site Identity: 26.6 N.A. N.A. 46.6 N.A. N.A.
P-Site Similarity: 53.3 N.A. N.A. 73.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 22 0 8 8 0 0 0 0 0 0 0 0 22 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 50 8 0 0 8 0 8 0 0 36 0 % D
% Glu: 0 0 8 0 0 0 15 8 0 22 72 8 8 8 0 % E
% Phe: 0 0 0 0 8 8 8 36 0 8 0 0 0 0 0 % F
% Gly: 0 0 0 58 8 0 0 0 0 0 0 8 8 15 0 % G
% His: 0 8 0 0 0 15 0 0 0 0 0 0 8 0 36 % H
% Ile: 0 8 8 0 0 0 43 0 15 0 0 0 0 0 0 % I
% Lys: 8 0 8 0 0 22 0 8 8 0 8 0 0 0 0 % K
% Leu: 36 8 15 15 0 0 8 0 58 0 8 8 72 15 8 % L
% Met: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 8 0 0 0 8 8 0 8 0 65 8 8 15 % P
% Gln: 22 0 58 15 8 36 0 0 8 50 0 8 0 0 8 % Q
% Arg: 8 0 0 0 0 0 0 15 0 0 0 0 0 0 8 % R
% Ser: 8 8 0 8 22 0 0 15 0 8 0 0 0 0 0 % S
% Thr: 8 43 0 0 0 0 8 8 0 0 0 0 0 0 0 % T
% Val: 0 8 0 0 0 0 15 8 0 8 0 0 0 0 8 % V
% Trp: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 8 0 0 8 0 8 8 0 0 15 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _