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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DDX18 All Species: 7.58
Human Site: T125 Identified Species: 12.82
UniProt: Q9NVP1 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NVP1 NP_006764.3 670 75407 T125 V N D A E P D T K K A K T E N
Chimpanzee Pan troglodytes XP_515753 670 75474 T125 V N D A E P D T K K A K T E N
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_533327 669 75188 D124 M V D D A G P D T K K S K T E
Cat Felis silvestris
Mouse Mus musculus Q8K363 660 74162 K115 V K K K K K K K R K M A N D A
Rat Rattus norvegicus NP_001006997 674 75530 A129 T E P D P K K A K T E E G T E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_422125 662 73819 P117 K R K A A A G P E G G T E T K
Frog Xenopus laevis NP_001084744 638 72228 S113 P E A S D Q E S K C E N H V E
Zebra Danio Brachydanio rerio NP_001003411 653 73486 G110 D T T Q A S A G E E E Q Q E E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VD51 680 76909 Q133 G S E D D D Q Q E D E D E E E
Honey Bee Apis mellifera XP_397167 429 49197
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783274 680 77265 E144 T D L A V T E E I L S D S S F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LIH9 568 63798 M69 E E E K V E A M E D G E D E K
Baker's Yeast Sacchar. cerevisiae Q03532 505 56699
Red Bread Mold Neurospora crassa Q7S2N9 578 64641 S79 G N G D K E D S D D K D A E A
Conservation
Percent
Protein Identity: 100 98.3 N.A. 89.6 N.A. 86.4 85.1 N.A. N.A. 73.5 73.7 71.9 N.A. 59.7 47.6 N.A. 55.8
Protein Similarity: 100 99 N.A. 95 N.A. 90.7 90.5 N.A. N.A. 82.2 84.6 82.6 N.A. 73.8 55.3 N.A. 70.2
P-Site Identity: 100 100 N.A. 13.3 N.A. 13.3 6.6 N.A. N.A. 6.6 6.6 6.6 N.A. 6.6 0 N.A. 6.6
P-Site Similarity: 100 100 N.A. 20 N.A. 33.3 13.3 N.A. N.A. 13.3 33.3 26.6 N.A. 33.3 0 N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. 47.6 48.6 50.9
Protein Similarity: N.A. N.A. N.A. 64.1 64 69.1
P-Site Identity: N.A. N.A. N.A. 6.6 0 20
P-Site Similarity: N.A. N.A. N.A. 26.6 0 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 29 22 8 15 8 0 0 15 8 8 0 15 % A
% Cys: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % C
% Asp: 8 8 22 29 15 8 22 8 8 22 0 22 8 8 0 % D
% Glu: 8 22 15 0 15 15 15 8 29 8 29 15 15 43 36 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % F
% Gly: 15 0 8 0 0 8 8 8 0 8 15 0 8 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % I
% Lys: 8 8 15 15 15 15 15 8 29 29 15 15 8 0 15 % K
% Leu: 0 0 8 0 0 0 0 0 0 8 0 0 0 0 0 % L
% Met: 8 0 0 0 0 0 0 8 0 0 8 0 0 0 0 % M
% Asn: 0 22 0 0 0 0 0 0 0 0 0 8 8 0 15 % N
% Pro: 8 0 8 0 8 15 8 8 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 8 0 8 8 8 0 0 0 8 8 0 0 % Q
% Arg: 0 8 0 0 0 0 0 0 8 0 0 0 0 0 0 % R
% Ser: 0 8 0 8 0 8 0 15 0 0 8 8 8 8 0 % S
% Thr: 15 8 8 0 0 8 0 15 8 8 0 8 15 22 0 % T
% Val: 22 8 0 0 15 0 0 0 0 0 0 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _