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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PNPO All Species: 26.06
Human Site: S128 Identified Species: 44.1
UniProt: Q9NVS9 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NVS9 NP_060599.1 261 29988 S128 L D S N P F A S L V F Y W E P
Chimpanzee Pan troglodytes XP_001173368 218 25181 M96 D G K P S A R M L L L K G F G
Rhesus Macaque Macaca mulatta XP_001084391 261 30077 S128 L D S N P F A S L V F Y W E P
Dog Lupus familis XP_537661 261 30047 S128 L D S N P F A S L V F Y W E P
Cat Felis silvestris
Mouse Mus musculus Q91XF0 261 30096 S128 L D S N P F A S L V F Y W E P
Rat Rattus norvegicus O88794 261 30166 S128 L D S N P F A S L V F Y W E P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519158 363 40331 S231 L N S N P F A S L V F Y W E P
Chicken Gallus gallus
Frog Xenopus laevis NP_001086328 228 26561 N106 L F Y W E P F N R Q V R I E G
Zebra Danio Brachydanio rerio XP_688664 277 31930 C145 L E S N P H A C L V F Y W E P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392591 241 28081 Q115 V E V N F Y W Q P L H R S V R
Nematode Worm Caenorhab. elegans Q20939 253 29384 P129 G N Q L E E N P N A A M L F Y
Sea Urchin Strong. purpuratus XP_785156 283 31956 A149 L A E N P F A A L V F Y W D F
Poplar Tree Populus trichocarpa XP_002301080 453 50823 S330 L S E N P H A S L L F Y W D G
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_568717 530 59357 A407 L S E N P S A A L L F Y W E I
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 83.1 98 92.3 N.A. 90 89.6 N.A. 44.6 N.A. 61.6 56.3 N.A. N.A. 44.4 40.6 49.8
Protein Similarity: 100 83.5 98.8 95 N.A. 93.8 93.4 N.A. 52 N.A. 71.2 72.9 N.A. N.A. 63.2 60.1 66
P-Site Identity: 100 6.6 100 100 N.A. 100 100 N.A. 93.3 N.A. 13.3 80 N.A. N.A. 6.6 0 66.6
P-Site Similarity: 100 13.3 100 100 N.A. 100 100 N.A. 100 N.A. 20 86.6 N.A. N.A. 33.3 6.6 80
Percent
Protein Identity: 30.9 N.A. N.A. 27.9 N.A. N.A.
Protein Similarity: 39.5 N.A. N.A. 35.4 N.A. N.A.
P-Site Identity: 60 N.A. N.A. 60 N.A. N.A.
P-Site Similarity: 73.3 N.A. N.A. 73.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 0 8 72 15 0 8 8 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % C
% Asp: 8 36 0 0 0 0 0 0 0 0 0 0 0 15 0 % D
% Glu: 0 15 22 0 15 8 0 0 0 0 0 0 0 65 0 % E
% Phe: 0 8 0 0 8 50 8 0 0 0 72 0 0 15 8 % F
% Gly: 8 8 0 0 0 0 0 0 0 0 0 0 8 0 22 % G
% His: 0 0 0 0 0 15 0 0 0 0 8 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 8 % I
% Lys: 0 0 8 0 0 0 0 0 0 0 0 8 0 0 0 % K
% Leu: 79 0 0 8 0 0 0 0 79 29 8 0 8 0 0 % L
% Met: 0 0 0 0 0 0 0 8 0 0 0 8 0 0 0 % M
% Asn: 0 15 0 79 0 0 8 8 8 0 0 0 0 0 0 % N
% Pro: 0 0 0 8 72 8 0 8 8 0 0 0 0 0 50 % P
% Gln: 0 0 8 0 0 0 0 8 0 8 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 8 0 8 0 0 15 0 0 8 % R
% Ser: 0 15 50 0 8 8 0 50 0 0 0 0 8 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 8 0 8 0 0 0 0 0 0 58 8 0 0 8 0 % V
% Trp: 0 0 0 8 0 0 8 0 0 0 0 0 72 0 0 % W
% Tyr: 0 0 8 0 0 8 0 0 0 0 0 72 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _