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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PNPO All Species: 32.42
Human Site: S164 Identified Species: 54.87
UniProt: Q9NVS9 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NVS9 NP_060599.1 261 29988 S164 Y F H S R P K S S Q I G A V V
Chimpanzee Pan troglodytes XP_001173368 218 25181 D122 S R K G K E L D S N P F A S L
Rhesus Macaque Macaca mulatta XP_001084391 261 30077 S164 Y F H S R P K S S Q I G A V V
Dog Lupus familis XP_537661 261 30047 S164 Y F H S R P K S S Q I G A V V
Cat Felis silvestris
Mouse Mus musculus Q91XF0 261 30096 S164 Y F H S R P K S S Q I G A V V
Rat Rattus norvegicus O88794 261 30166 S164 Y F H S R P K S S Q I G A V V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519158 363 40331 S267 Y F R S R P K S S Q I G A V V
Chicken Gallus gallus
Frog Xenopus laevis NP_001086328 228 26561 K132 K Y F H S R P K S S Q I G A V
Zebra Danio Brachydanio rerio XP_688664 277 31930 S181 Y F H S R P K S S Q I G A V V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392591 241 28081 A145 Y F Q S R P Y A S Q I G S M A
Nematode Worm Caenorhab. elegans Q20939 253 29384 E156 V V E K L P D E M A V A Y W N
Sea Urchin Strong. purpuratus XP_785156 283 31956 T185 Y F H S R P K T S Q I G A V V
Poplar Tree Populus trichocarpa XP_002301080 453 50823 S356 Q K V P D E E S E Q Y F H S R
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_568717 530 59357 E434 R I P E S E S E N Y F H S R P
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 83.1 98 92.3 N.A. 90 89.6 N.A. 44.6 N.A. 61.6 56.3 N.A. N.A. 44.4 40.6 49.8
Protein Similarity: 100 83.5 98.8 95 N.A. 93.8 93.4 N.A. 52 N.A. 71.2 72.9 N.A. N.A. 63.2 60.1 66
P-Site Identity: 100 13.3 100 100 N.A. 100 100 N.A. 93.3 N.A. 13.3 100 N.A. N.A. 60 6.6 93.3
P-Site Similarity: 100 26.6 100 100 N.A. 100 100 N.A. 93.3 N.A. 20 100 N.A. N.A. 80 13.3 100
Percent
Protein Identity: 30.9 N.A. N.A. 27.9 N.A. N.A.
Protein Similarity: 39.5 N.A. N.A. 35.4 N.A. N.A.
P-Site Identity: 13.3 N.A. N.A. 0 N.A. N.A.
P-Site Similarity: 20 N.A. N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 8 0 8 0 8 65 8 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 8 0 8 8 0 0 0 0 0 0 0 % D
% Glu: 0 0 8 8 0 22 8 15 8 0 0 0 0 0 0 % E
% Phe: 0 65 8 0 0 0 0 0 0 0 8 15 0 0 0 % F
% Gly: 0 0 0 8 0 0 0 0 0 0 0 65 8 0 0 % G
% His: 0 0 50 8 0 0 0 0 0 0 0 8 8 0 0 % H
% Ile: 0 8 0 0 0 0 0 0 0 0 65 8 0 0 0 % I
% Lys: 8 8 8 8 8 0 58 8 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 8 0 8 0 0 0 0 0 0 0 8 % L
% Met: 0 0 0 0 0 0 0 0 8 0 0 0 0 8 0 % M
% Asn: 0 0 0 0 0 0 0 0 8 8 0 0 0 0 8 % N
% Pro: 0 0 8 8 0 72 8 0 0 0 8 0 0 0 8 % P
% Gln: 8 0 8 0 0 0 0 0 0 72 8 0 0 0 0 % Q
% Arg: 8 8 8 0 65 8 0 0 0 0 0 0 0 8 8 % R
% Ser: 8 0 0 65 15 0 8 58 79 8 0 0 15 15 0 % S
% Thr: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % T
% Val: 8 8 8 0 0 0 0 0 0 0 8 0 0 58 65 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % W
% Tyr: 65 8 0 0 0 0 8 0 0 8 8 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _