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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PNPO All Species: 40.3
Human Site: T111 Identified Species: 68.21
UniProt: Q9NVS9 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NVS9 NP_060599.1 261 29988 T111 K D G F R F F T N F E S R K G
Chimpanzee Pan troglodytes XP_001173368 218 25181 N79 C P D I G E A N A M C L A T C
Rhesus Macaque Macaca mulatta XP_001084391 261 30077 T111 K D G F R F F T N F E S R K G
Dog Lupus familis XP_537661 261 30047 T111 K D G F R F F T N F E S R K G
Cat Felis silvestris
Mouse Mus musculus Q91XF0 261 30096 T111 K D G F R F F T N Y E S R K G
Rat Rattus norvegicus O88794 261 30166 T111 K D G F R F F T N Y E S R K G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519158 363 40331 T214 Q D G F R F F T N L E S R K G
Chicken Gallus gallus
Frog Xenopus laevis NP_001086328 228 26561 D89 R E S R K G L D L E T N P V A
Zebra Danio Brachydanio rerio XP_688664 277 31930 S128 E E G F C F F S N Y E S R K G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392591 241 28081 K98 Y T N Y E S R K A R E I A E N
Nematode Worm Caenorhab. elegans Q20939 253 29384 S112 A Y T P T G F S F Y T N Y T S
Sea Urchin Strong. purpuratus XP_785156 283 31956 T132 E T G F R F Y T N Y E S R K G
Poplar Tree Populus trichocarpa XP_002301080 453 50823 T313 K D G F V W Y T N Y E S Q K A
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_568717 530 59357 T390 E N G F V W F T N Y E S K K G
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 83.1 98 92.3 N.A. 90 89.6 N.A. 44.6 N.A. 61.6 56.3 N.A. N.A. 44.4 40.6 49.8
Protein Similarity: 100 83.5 98.8 95 N.A. 93.8 93.4 N.A. 52 N.A. 71.2 72.9 N.A. N.A. 63.2 60.1 66
P-Site Identity: 100 0 100 100 N.A. 93.3 93.3 N.A. 86.6 N.A. 0 66.6 N.A. N.A. 6.6 6.6 73.3
P-Site Similarity: 100 0 100 100 N.A. 100 100 N.A. 93.3 N.A. 26.6 93.3 N.A. N.A. 20 26.6 93.3
Percent
Protein Identity: 30.9 N.A. N.A. 27.9 N.A. N.A.
Protein Similarity: 39.5 N.A. N.A. 35.4 N.A. N.A.
P-Site Identity: 60 N.A. N.A. 60 N.A. N.A.
P-Site Similarity: 86.6 N.A. N.A. 93.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 0 0 8 0 15 0 0 0 15 0 15 % A
% Cys: 8 0 0 0 8 0 0 0 0 0 8 0 0 0 8 % C
% Asp: 0 50 8 0 0 0 0 8 0 0 0 0 0 0 0 % D
% Glu: 22 15 0 0 8 8 0 0 0 8 79 0 0 8 0 % E
% Phe: 0 0 0 72 0 58 65 0 8 22 0 0 0 0 0 % F
% Gly: 0 0 72 0 8 15 0 0 0 0 0 0 0 0 65 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 8 0 0 0 0 0 0 0 8 0 0 0 % I
% Lys: 43 0 0 0 8 0 0 8 0 0 0 0 8 72 0 % K
% Leu: 0 0 0 0 0 0 8 0 8 8 0 8 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % M
% Asn: 0 8 8 0 0 0 0 8 72 0 0 15 0 0 8 % N
% Pro: 0 8 0 8 0 0 0 0 0 0 0 0 8 0 0 % P
% Gln: 8 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % Q
% Arg: 8 0 0 8 50 0 8 0 0 8 0 0 58 0 0 % R
% Ser: 0 0 8 0 0 8 0 15 0 0 0 72 0 0 8 % S
% Thr: 0 15 8 0 8 0 0 65 0 0 15 0 0 15 0 % T
% Val: 0 0 0 0 15 0 0 0 0 0 0 0 0 8 0 % V
% Trp: 0 0 0 0 0 15 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 8 0 8 0 0 15 0 0 50 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _