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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PNPO All Species: 38.18
Human Site: Y132 Identified Species: 64.62
UniProt: Q9NVS9 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.23
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NVS9 NP_060599.1 261 29988 Y132 P F A S L V F Y W E P L N R Q
Chimpanzee Pan troglodytes XP_001173368 218 25181 K100 S A R M L L L K G F G K D G F
Rhesus Macaque Macaca mulatta XP_001084391 261 30077 Y132 P F A S L V F Y W E P L N R Q
Dog Lupus familis XP_537661 261 30047 Y132 P F A S L V F Y W E P L N R Q
Cat Felis silvestris
Mouse Mus musculus Q91XF0 261 30096 Y132 P F A S L V F Y W E P L N R Q
Rat Rattus norvegicus O88794 261 30166 Y132 P F A S L V F Y W E P L N R Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519158 363 40331 Y235 P F A S L V F Y W E P L N R Q
Chicken Gallus gallus
Frog Xenopus laevis NP_001086328 228 26561 R110 E P F N R Q V R I E G S V E R
Zebra Danio Brachydanio rerio XP_688664 277 31930 Y149 P H A C L V F Y W E P L N R Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392591 241 28081 R119 F Y W Q P L H R S V R I A G T
Nematode Worm Caenorhab. elegans Q20939 253 29384 M133 E E N P N A A M L F Y W P K V
Sea Urchin Strong. purpuratus XP_785156 283 31956 Y153 P F A A L V F Y W D F Q S R S
Poplar Tree Populus trichocarpa XP_002301080 453 50823 Y334 P H A S L L F Y W D G L N R Q
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_568717 530 59357 Y411 P S A A L L F Y W E I L N R Q
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 83.1 98 92.3 N.A. 90 89.6 N.A. 44.6 N.A. 61.6 56.3 N.A. N.A. 44.4 40.6 49.8
Protein Similarity: 100 83.5 98.8 95 N.A. 93.8 93.4 N.A. 52 N.A. 71.2 72.9 N.A. N.A. 63.2 60.1 66
P-Site Identity: 100 6.6 100 100 N.A. 100 100 N.A. 100 N.A. 6.6 86.6 N.A. N.A. 0 0 60
P-Site Similarity: 100 20 100 100 N.A. 100 100 N.A. 100 N.A. 20 86.6 N.A. N.A. 20 6.6 80
Percent
Protein Identity: 30.9 N.A. N.A. 27.9 N.A. N.A.
Protein Similarity: 39.5 N.A. N.A. 35.4 N.A. N.A.
P-Site Identity: 73.3 N.A. N.A. 73.3 N.A. N.A.
P-Site Similarity: 86.6 N.A. N.A. 86.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 72 15 0 8 8 0 0 0 0 0 8 0 0 % A
% Cys: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 15 0 0 8 0 0 % D
% Glu: 15 8 0 0 0 0 0 0 0 65 0 0 0 8 0 % E
% Phe: 8 50 8 0 0 0 72 0 0 15 8 0 0 0 8 % F
% Gly: 0 0 0 0 0 0 0 0 8 0 22 0 0 15 0 % G
% His: 0 15 0 0 0 0 8 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 8 0 8 8 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 8 0 0 0 8 0 8 0 % K
% Leu: 0 0 0 0 79 29 8 0 8 0 0 65 0 0 0 % L
% Met: 0 0 0 8 0 0 0 8 0 0 0 0 0 0 0 % M
% Asn: 0 0 8 8 8 0 0 0 0 0 0 0 65 0 0 % N
% Pro: 72 8 0 8 8 0 0 0 0 0 50 0 8 0 0 % P
% Gln: 0 0 0 8 0 8 0 0 0 0 0 8 0 0 65 % Q
% Arg: 0 0 8 0 8 0 0 15 0 0 8 0 0 72 8 % R
% Ser: 8 8 0 50 0 0 0 0 8 0 0 8 8 0 8 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % T
% Val: 0 0 0 0 0 58 8 0 0 8 0 0 8 0 8 % V
% Trp: 0 0 8 0 0 0 0 0 72 0 0 8 0 0 0 % W
% Tyr: 0 8 0 0 0 0 0 72 0 0 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _