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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PNPO All Species: 26.36
Human Site: Y41 Identified Species: 44.62
UniProt: Q9NVS9 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NVS9 NP_060599.1 261 29988 Y41 L G P M R K S Y R G D R E A F
Chimpanzee Pan troglodytes XP_001173368 218 25181 G27 G Y L S H L C G R S A A M D L
Rhesus Macaque Macaca mulatta XP_001084391 261 30077 Y41 L G P M R K S Y R G D R E A F
Dog Lupus familis XP_537661 261 30047 Y41 L G P M R K S Y R G D R E A F
Cat Felis silvestris
Mouse Mus musculus Q91XF0 261 30096 Y41 L G P M R K S Y R G D R E A F
Rat Rattus norvegicus O88794 261 30166 Y41 L G P M R K S Y R G D R E A F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519158 363 40331 L46 L L Q V L L L L Q V L Q V L L
Chicken Gallus gallus
Frog Xenopus laevis NP_001086328 228 26561 E37 Q F N D W F Q E V T Q C P A I
Zebra Danio Brachydanio rerio XP_688664 277 31930 Y58 L S N M R K T Y K S D Q E C F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392591 241 28081 R44 K E P I G Q F R A W F D E A C
Nematode Worm Caenorhab. elegans Q20939 253 29384 K54 D P Y L L E S K L P T T S P F
Sea Urchin Strong. purpuratus XP_785156 283 31956 Y60 V A A M R K S Y K A G H Q A F
Poplar Tree Populus trichocarpa XP_002301080 453 50823 Y247 I S A L R Q N Y I S P E L L E
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_568717 530 59357 N64 C T K V I I P N M Q D S G S P
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 83.1 98 92.3 N.A. 90 89.6 N.A. 44.6 N.A. 61.6 56.3 N.A. N.A. 44.4 40.6 49.8
Protein Similarity: 100 83.5 98.8 95 N.A. 93.8 93.4 N.A. 52 N.A. 71.2 72.9 N.A. N.A. 63.2 60.1 66
P-Site Identity: 100 6.6 100 100 N.A. 100 100 N.A. 6.6 N.A. 6.6 53.3 N.A. N.A. 20 13.3 46.6
P-Site Similarity: 100 6.6 100 100 N.A. 100 100 N.A. 26.6 N.A. 6.6 73.3 N.A. N.A. 33.3 26.6 66.6
Percent
Protein Identity: 30.9 N.A. N.A. 27.9 N.A. N.A.
Protein Similarity: 39.5 N.A. N.A. 35.4 N.A. N.A.
P-Site Identity: 13.3 N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: 40 N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 15 0 0 0 0 0 8 8 8 8 0 58 0 % A
% Cys: 8 0 0 0 0 0 8 0 0 0 0 8 0 8 8 % C
% Asp: 8 0 0 8 0 0 0 0 0 0 50 8 0 8 0 % D
% Glu: 0 8 0 0 0 8 0 8 0 0 0 8 50 0 8 % E
% Phe: 0 8 0 0 0 8 8 0 0 0 8 0 0 0 58 % F
% Gly: 8 36 0 0 8 0 0 8 0 36 8 0 8 0 0 % G
% His: 0 0 0 0 8 0 0 0 0 0 0 8 0 0 0 % H
% Ile: 8 0 0 8 8 8 0 0 8 0 0 0 0 0 8 % I
% Lys: 8 0 8 0 0 50 0 8 15 0 0 0 0 0 0 % K
% Leu: 50 8 8 15 15 15 8 8 8 0 8 0 8 15 15 % L
% Met: 0 0 0 50 0 0 0 0 8 0 0 0 8 0 0 % M
% Asn: 0 0 15 0 0 0 8 8 0 0 0 0 0 0 0 % N
% Pro: 0 8 43 0 0 0 8 0 0 8 8 0 8 8 8 % P
% Gln: 8 0 8 0 0 15 8 0 8 8 8 15 8 0 0 % Q
% Arg: 0 0 0 0 58 0 0 8 43 0 0 36 0 0 0 % R
% Ser: 0 15 0 8 0 0 50 0 0 22 0 8 8 8 0 % S
% Thr: 0 8 0 0 0 0 8 0 0 8 8 8 0 0 0 % T
% Val: 8 0 0 15 0 0 0 0 8 8 0 0 8 0 0 % V
% Trp: 0 0 0 0 8 0 0 0 0 8 0 0 0 0 0 % W
% Tyr: 0 8 8 0 0 0 0 58 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _