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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NLE1 All Species: 28.18
Human Site: S395 Identified Species: 47.69
UniProt: Q9NVX2 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NVX2 NP_001014445.1 485 53266 S395 A S A S F D K S I K L W D G R
Chimpanzee Pan troglodytes XP_001174396 452 49610 S362 A S A S F D K S I K L W D G R
Rhesus Macaque Macaca mulatta XP_001113853 485 53205 S395 A S A S F D K S I K L W D G R
Dog Lupus familis XP_548262 468 51088 S381 A S A S F D K S I K L W D G R
Cat Felis silvestris
Mouse Mus musculus Q8VEJ4 485 53130 S395 A S A S F D K S I K L W D G R
Rat Rattus norvegicus Q5BK30 415 45841 I338 N A T T R K C I T K L E G H E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_415857 482 53449 S392 A S A S F D K S I K L W E G R
Frog Xenopus laevis Q5FWQ6 415 45899 L338 S A S S R K C L A K L E G H E
Zebra Danio Brachydanio rerio Q803D2 410 46511 T333 S T G M C L M T L V G H D N W
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V3J8 361 39023 K283 L K T Y T G H K N E K Y C I F
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q17963 376 40375 N299 K Q Y T G H E N S K Y C I F A
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001148971 471 52128 G387 K S V K L W N G I T G K F V A
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FLX9 473 52879 I390 S V R L W N G I T G Q F V T V
Baker's Yeast Sacchar. cerevisiae P25382 515 57007 S425 V S A S F D N S I K L W D G R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 88.4 98.3 86.8 N.A. 95.4 25.3 N.A. N.A. 83.3 24.5 22.6 N.A. 25.5 N.A. 24.5 N.A.
Protein Similarity: 100 90.5 99.1 90.5 N.A. 97.9 43.7 N.A. N.A. 91.5 44.5 41.2 N.A. 40.2 N.A. 40.8 N.A.
P-Site Identity: 100 100 100 100 N.A. 100 13.3 N.A. N.A. 93.3 20 6.6 N.A. 0 N.A. 6.6 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 26.6 N.A. N.A. 100 40 33.3 N.A. 13.3 N.A. 26.6 N.A.
Percent
Protein Identity: N.A. 57.9 N.A. 55 45.6 N.A.
Protein Similarity: N.A. 73.2 N.A. 71.5 64.4 N.A.
P-Site Identity: N.A. 13.3 N.A. 0 86.6 N.A.
P-Site Similarity: N.A. 13.3 N.A. 26.6 86.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 43 15 50 0 0 0 0 0 8 0 0 0 0 0 15 % A
% Cys: 0 0 0 0 8 0 15 0 0 0 0 8 8 0 0 % C
% Asp: 0 0 0 0 0 50 0 0 0 0 0 0 50 0 0 % D
% Glu: 0 0 0 0 0 0 8 0 0 8 0 15 8 0 15 % E
% Phe: 0 0 0 0 50 0 0 0 0 0 0 8 8 8 8 % F
% Gly: 0 0 8 0 8 8 8 8 0 8 15 0 15 50 0 % G
% His: 0 0 0 0 0 8 8 0 0 0 0 8 0 15 0 % H
% Ile: 0 0 0 0 0 0 0 15 58 0 0 0 8 8 0 % I
% Lys: 15 8 0 8 0 15 43 8 0 72 8 8 0 0 0 % K
% Leu: 8 0 0 8 8 8 0 8 8 0 65 0 0 0 0 % L
% Met: 0 0 0 8 0 0 8 0 0 0 0 0 0 0 0 % M
% Asn: 8 0 0 0 0 8 15 8 8 0 0 0 0 8 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 8 0 0 0 0 0 0 0 0 8 0 0 0 0 % Q
% Arg: 0 0 8 0 15 0 0 0 0 0 0 0 0 0 50 % R
% Ser: 22 58 8 58 0 0 0 50 8 0 0 0 0 0 0 % S
% Thr: 0 8 15 15 8 0 0 8 15 8 0 0 0 8 0 % T
% Val: 8 8 8 0 0 0 0 0 0 8 0 0 8 8 8 % V
% Trp: 0 0 0 0 8 8 0 0 0 0 0 50 0 0 8 % W
% Tyr: 0 0 8 8 0 0 0 0 0 0 8 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _