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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NLE1 All Species: 22.73
Human Site: S434 Identified Species: 38.46
UniProt: Q9NVX2 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NVX2 NP_001014445.1 485 53266 S434 R L L V S G S S D S T L K V W
Chimpanzee Pan troglodytes XP_001174396 452 49610 S401 R L L V S G S S D S T L K V W
Rhesus Macaque Macaca mulatta XP_001113853 485 53205 S434 R L L V S G S S D S T L K V W
Dog Lupus familis XP_548262 468 51088 S420 R L L V S G S S D S T L K V W
Cat Felis silvestris
Mouse Mus musculus Q8VEJ4 485 53130 S434 R L L V S G S S D S T L K V W
Rat Rattus norvegicus Q5BK30 415 45841 G377 R I W D V Q T G Q C L Q V L E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_415857 482 53449 S431 R L L V S G S S D S T L K V W
Frog Xenopus laevis Q5FWQ6 415 45899 G377 R L W D P H T G E C L Q V L K
Zebra Danio Brachydanio rerio Q803D2 410 46511 C372 W D Y K N K R C M K T L S A H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V3J8 361 39023 Q322 L Q S K E V V Q K L Q G H T D
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q17963 376 40375 C338 Q T R E I V Q C L E G H T Q P
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001148971 471 52128 I426 S K D S T L K I W D I R T H K
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FLX9 473 52879 W429 K D S T L K I W E I R T K K L
Baker's Yeast Sacchar. cerevisiae P25382 515 57007 K464 R L L V S C S K D T T L K V W
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 88.4 98.3 86.8 N.A. 95.4 25.3 N.A. N.A. 83.3 24.5 22.6 N.A. 25.5 N.A. 24.5 N.A.
Protein Similarity: 100 90.5 99.1 90.5 N.A. 97.9 43.7 N.A. N.A. 91.5 44.5 41.2 N.A. 40.2 N.A. 40.8 N.A.
P-Site Identity: 100 100 100 100 N.A. 100 6.6 N.A. N.A. 100 13.3 13.3 N.A. 0 N.A. 0 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 26.6 N.A. N.A. 100 33.3 20 N.A. 0 N.A. 6.6 N.A.
Percent
Protein Identity: N.A. 57.9 N.A. 55 45.6 N.A.
Protein Similarity: N.A. 73.2 N.A. 71.5 64.4 N.A.
P-Site Identity: N.A. 0 N.A. 6.6 80 N.A.
P-Site Similarity: N.A. 6.6 N.A. 20 86.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % A
% Cys: 0 0 0 0 0 8 0 15 0 15 0 0 0 0 0 % C
% Asp: 0 15 8 15 0 0 0 0 50 8 0 0 0 0 8 % D
% Glu: 0 0 0 8 8 0 0 0 15 8 0 0 0 0 8 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 43 0 15 0 0 8 8 0 0 0 % G
% His: 0 0 0 0 0 8 0 0 0 0 0 8 8 8 8 % H
% Ile: 0 8 0 0 8 0 8 8 0 8 8 0 0 0 0 % I
% Lys: 8 8 0 15 0 15 8 8 8 8 0 0 58 8 15 % K
% Leu: 8 58 50 0 8 8 0 0 8 8 15 58 0 15 8 % L
% Met: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 8 % P
% Gln: 8 8 0 0 0 8 8 8 8 0 8 15 0 8 0 % Q
% Arg: 65 0 8 0 0 0 8 0 0 0 8 8 0 0 0 % R
% Ser: 8 0 15 8 50 0 50 43 0 43 0 0 8 0 0 % S
% Thr: 0 8 0 8 8 0 15 0 0 8 58 8 15 8 0 % T
% Val: 0 0 0 50 8 15 8 0 0 0 0 0 15 50 0 % V
% Trp: 8 0 15 0 0 0 0 8 8 0 0 0 0 0 50 % W
% Tyr: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _