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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMEM45A
All Species:
12.42
Human Site:
S256
Identified Species:
27.33
UniProt:
Q9NWC5
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NWC5
NP_060474.1
275
31680
S256
S
R
L
K
R
L
C
S
S
E
V
G
L
L
K
Chimpanzee
Pan troglodytes
XP_516625
310
35385
W272
G
P
H
L
L
R
G
W
K
A
F
K
I
S
A
Rhesus Macaque
Macaca mulatta
XP_001093702
275
31596
S256
S
R
L
K
R
L
C
S
S
E
V
G
L
L
K
Dog
Lupus familis
XP_535720
275
31594
P256
S
R
L
T
R
F
C
P
S
E
V
G
L
L
K
Cat
Felis silvestris
Mouse
Mus musculus
Q60774
273
31324
T254
S
R
L
R
K
G
C
T
S
E
V
G
L
L
K
Rat
Rattus norvegicus
Q497B2
278
32319
G253
R
V
R
R
R
A
E
G
E
I
I
G
I
Q
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514618
275
31990
P256
S
R
V
K
Q
I
Y
P
S
E
M
G
L
L
K
Chicken
Gallus gallus
XP_416606
275
31774
S256
S
K
I
K
Q
S
Q
S
M
E
M
G
L
L
K
Frog
Xenopus laevis
Q6NS09
280
31983
I254
R
H
K
K
L
P
V
I
V
D
N
G
L
I
K
Zebra Danio
Brachydanio rerio
Q6P0S3
283
32742
G256
W
C
E
R
R
Q
R
G
D
M
E
M
G
L
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783137
274
30760
K254
A
C
G
F
S
S
V
K
Y
S
Q
M
S
N
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
81.2
94.9
77.8
N.A.
64.3
43.1
N.A.
64.3
54.1
43.9
45.5
N.A.
N.A.
N.A.
N.A.
32.7
Protein Similarity:
100
84.1
98.1
88
N.A.
80.7
64.3
N.A.
78.9
74.5
65
62.5
N.A.
N.A.
N.A.
N.A.
49.4
P-Site Identity:
100
0
100
80
N.A.
73.3
20
N.A.
60
53.3
26.6
13.3
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
6.6
100
80
N.A.
93.3
40
N.A.
86.6
80
40
26.6
N.A.
N.A.
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
0
10
0
0
0
10
0
0
0
0
10
% A
% Cys:
0
19
0
0
0
0
37
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
10
10
0
0
0
0
0
% D
% Glu:
0
0
10
0
0
0
10
0
10
55
10
0
0
0
0
% E
% Phe:
0
0
0
10
0
10
0
0
0
0
10
0
0
0
0
% F
% Gly:
10
0
10
0
0
10
10
19
0
0
0
73
10
0
10
% G
% His:
0
10
10
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
10
0
0
10
0
10
0
10
10
0
19
10
0
% I
% Lys:
0
10
10
46
10
0
0
10
10
0
0
10
0
0
73
% K
% Leu:
0
0
37
10
19
19
0
0
0
0
0
0
64
64
0
% L
% Met:
0
0
0
0
0
0
0
0
10
10
19
19
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
10
0
0
10
0
% N
% Pro:
0
10
0
0
0
10
0
19
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
19
10
10
0
0
0
10
0
0
10
0
% Q
% Arg:
19
46
10
28
46
10
10
0
0
0
0
0
0
0
10
% R
% Ser:
55
0
0
0
10
19
0
28
46
10
0
0
10
10
0
% S
% Thr:
0
0
0
10
0
0
0
10
0
0
0
0
0
0
0
% T
% Val:
0
10
10
0
0
0
19
0
10
0
37
0
0
0
0
% V
% Trp:
10
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
10
0
10
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _