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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
THG1L
All Species:
29.09
Human Site:
S222
Identified Species:
49.23
UniProt:
Q9NWX6
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NWX6
NP_060342.2
298
34831
S222
D
K
N
E
I
L
F
S
E
F
N
I
N
Y
N
Chimpanzee
Pan troglodytes
XP_518066
298
34800
S222
D
K
N
E
I
L
F
S
E
F
N
I
N
Y
N
Rhesus Macaque
Macaca mulatta
XP_001113603
298
34781
S222
D
K
N
E
I
L
F
S
E
F
N
I
N
Y
N
Dog
Lupus familis
XP_536453
398
45751
S322
D
K
N
E
I
L
F
S
E
F
N
I
N
Y
N
Cat
Felis silvestris
Mouse
Mus musculus
Q9CY52
298
34952
S222
D
K
N
E
I
L
F
S
E
F
H
I
N
Y
N
Rat
Rattus norvegicus
Q5M965
298
34831
S222
D
K
N
E
I
L
F
S
E
F
H
I
N
Y
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507734
269
31692
P204
I
N
Y
N
N
E
S
P
M
Y
R
K
G
T
V
Chicken
Gallus gallus
NP_001025787
269
31994
L204
I
N
Y
N
N
E
P
L
M
Y
R
K
G
T
V
Frog
Xenopus laevis
NP_001088597
286
33655
S210
E
K
N
E
I
L
F
S
D
F
N
I
N
Y
N
Zebra Danio
Brachydanio rerio
NP_001007456
269
31543
S204
I
N
Y
N
N
E
S
S
V
Y
K
K
G
T
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3N8
286
33054
L211
M
Y
R
K
G
T
I
L
L
R
K
R
V
I
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_792143
265
30598
A201
Q
F
D
I
N
Y
N
A
E
P
E
I
F
R
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53215
237
27738
L173
Q
L
I
I
K
C
G
L
T
P
Q
E
S
E
K
Red Bread Mold
Neurospora crassa
Q7SDM8
293
33586
S212
P
E
M
F
K
K
G
S
V
V
F
R
N
Y
E
Conservation
Percent
Protein Identity:
100
98.9
96.9
68
N.A.
82.2
84.2
N.A.
77.5
76.1
59.4
63.7
N.A.
48.6
N.A.
N.A.
51
Protein Similarity:
100
98.9
97.3
71.6
N.A.
89.5
90.9
N.A.
82.8
82.5
73.1
75.5
N.A.
64.4
N.A.
N.A.
66.1
P-Site Identity:
100
100
100
100
N.A.
93.3
93.3
N.A.
0
0
86.6
6.6
N.A.
0
N.A.
N.A.
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
6.6
6.6
100
13.3
N.A.
6.6
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
40.6
47.6
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
55.3
63
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
20
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% C
% Asp:
43
0
8
0
0
0
0
0
8
0
0
0
0
0
0
% D
% Glu:
8
8
0
50
0
22
0
0
50
0
8
8
0
8
8
% E
% Phe:
0
8
0
8
0
0
50
0
0
50
8
0
8
0
0
% F
% Gly:
0
0
0
0
8
0
15
0
0
0
0
0
22
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
15
0
0
0
0
% H
% Ile:
22
0
8
15
50
0
8
0
0
0
0
58
0
8
0
% I
% Lys:
0
50
0
8
15
8
0
0
0
0
15
22
0
0
15
% K
% Leu:
0
8
0
0
0
50
0
22
8
0
0
0
0
0
8
% L
% Met:
8
0
8
0
0
0
0
0
15
0
0
0
0
0
0
% M
% Asn:
0
22
50
22
29
0
8
0
0
0
36
0
58
0
50
% N
% Pro:
8
0
0
0
0
0
8
8
0
15
0
0
0
0
0
% P
% Gln:
15
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% Q
% Arg:
0
0
8
0
0
0
0
0
0
8
15
15
0
8
0
% R
% Ser:
0
0
0
0
0
0
15
65
0
0
0
0
8
0
0
% S
% Thr:
0
0
0
0
0
8
0
0
8
0
0
0
0
22
8
% T
% Val:
0
0
0
0
0
0
0
0
15
8
0
0
8
0
15
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
22
0
0
8
0
0
0
22
0
0
0
58
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _