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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IRAK4
All Species:
22.12
Human Site:
S186
Identified Species:
44.24
UniProt:
Q9NWZ3
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NWZ3
NP_001107654.1
460
51530
S186
N
F
D
E
R
P
I
S
V
G
G
N
K
M
G
Chimpanzee
Pan troglodytes
XP_001166114
460
51588
S186
N
F
D
E
R
P
I
S
V
G
G
N
K
M
G
Rhesus Macaque
Macaca mulatta
NP_001129573
460
51601
S186
N
F
D
E
R
P
I
S
V
G
G
N
K
M
G
Dog
Lupus familis
XP_543727
460
51521
S186
N
F
D
E
R
P
I
S
L
G
G
N
K
M
G
Cat
Felis silvestris
Mouse
Mus musculus
Q8R4K2
459
50853
S186
N
F
D
E
Q
P
A
S
A
G
G
N
R
M
G
Rat
Rattus norvegicus
NP_001100261
461
51050
S188
D
F
D
E
R
P
V
S
I
G
G
N
R
M
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521647
280
31332
E57
Q
L
H
I
R
R
F
E
G
L
I
Q
M
G
K
Chicken
Gallus gallus
NP_001025909
373
40585
A150
L
P
E
A
V
G
M
A
Q
E
V
T
L
P
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_956457
382
41751
E159
D
S
N
K
P
V
Q
E
Q
E
L
F
V
E
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784716
406
45182
R180
L
K
S
L
C
R
L
R
H
P
N
L
V
I
L
Poplar Tree
Populus trichocarpa
XP_002322185
562
63055
F258
I
D
E
A
T
S
Q
F
D
E
S
R
K
I
G
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_198715
880
97935
I531
D
F
E
E
K
L
I
I
G
V
G
G
F
G
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
98.6
92.8
N.A.
83.9
84.3
N.A.
45.2
47.3
N.A.
39.1
N.A.
N.A.
N.A.
N.A.
33.9
Protein Similarity:
100
99.5
99.1
96.3
N.A.
90.8
91.9
N.A.
51.9
58.2
N.A.
54.7
N.A.
N.A.
N.A.
N.A.
51
P-Site Identity:
100
100
100
93.3
N.A.
73.3
73.3
N.A.
6.6
0
N.A.
0
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
100
100
100
N.A.
86.6
100
N.A.
6.6
20
N.A.
20
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
28.1
N.A.
N.A.
21.5
N.A.
N.A.
Protein Similarity:
47.5
N.A.
N.A.
34.4
N.A.
N.A.
P-Site Identity:
13.3
N.A.
N.A.
26.6
N.A.
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
46.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
17
0
0
9
9
9
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
25
9
50
0
0
0
0
0
9
0
0
0
0
0
0
% D
% Glu:
0
0
25
59
0
0
0
17
0
25
0
0
0
9
0
% E
% Phe:
0
59
0
0
0
0
9
9
0
0
0
9
9
0
0
% F
% Gly:
0
0
0
0
0
9
0
0
17
50
59
9
0
17
59
% G
% His:
0
0
9
0
0
0
0
0
9
0
0
0
0
0
0
% H
% Ile:
9
0
0
9
0
0
42
9
9
0
9
0
0
17
0
% I
% Lys:
0
9
0
9
9
0
0
0
0
0
0
0
42
0
9
% K
% Leu:
17
9
0
9
0
9
9
0
9
9
9
9
9
0
17
% L
% Met:
0
0
0
0
0
0
9
0
0
0
0
0
9
50
0
% M
% Asn:
42
0
9
0
0
0
0
0
0
0
9
50
0
0
0
% N
% Pro:
0
9
0
0
9
50
0
0
0
9
0
0
0
9
9
% P
% Gln:
9
0
0
0
9
0
17
0
17
0
0
9
0
0
0
% Q
% Arg:
0
0
0
0
50
17
0
9
0
0
0
9
17
0
0
% R
% Ser:
0
9
9
0
0
9
0
50
0
0
9
0
0
0
9
% S
% Thr:
0
0
0
0
9
0
0
0
0
0
0
9
0
0
0
% T
% Val:
0
0
0
0
9
9
9
0
25
9
9
0
17
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _