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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: IRAK4 All Species: 22.73
Human Site: Y48 Identified Species: 45.45
UniProt: Q9NWZ3 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NWZ3 NP_001107654.1 460 51530 Y48 K P S G D D R Y N Q F H I R R
Chimpanzee Pan troglodytes XP_001166114 460 51588 Y48 K P S G D D R Y N Q F H I R R
Rhesus Macaque Macaca mulatta NP_001129573 460 51601 Y48 K P S G D D R Y N Q F H I R R
Dog Lupus familis XP_543727 460 51521 Y48 K P S G D D R Y N Q F H I R R
Cat Felis silvestris
Mouse Mus musculus Q8R4K2 459 50853 Y48 K P S G D D R Y N Q F H I R R
Rat Rattus norvegicus NP_001100261 461 51050 Y48 K P S G D D R Y N Q F H I R R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521647 280 31332
Chicken Gallus gallus NP_001025909 373 40585 R15 R V A A A G G R P A A P A R G
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_956457 382 41751 L24 A L R A L A D L L D P Q D T W
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784716 406 45182 A43 G E M H H L A A M D A L L P G
Poplar Tree Populus trichocarpa XP_002322185 562 63055 F104 V P G V E R L F I A G D M I S
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_198715 880 97935 D194 F Y S K G G F D D V V R N V G
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 98.6 92.8 N.A. 83.9 84.3 N.A. 45.2 47.3 N.A. 39.1 N.A. N.A. N.A. N.A. 33.9
Protein Similarity: 100 99.5 99.1 96.3 N.A. 90.8 91.9 N.A. 51.9 58.2 N.A. 54.7 N.A. N.A. N.A. N.A. 51
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 0 6.6 N.A. 0 N.A. N.A. N.A. N.A. 0
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 0 20 N.A. 0 N.A. N.A. N.A. N.A. 6.6
Percent
Protein Identity: 28.1 N.A. N.A. 21.5 N.A. N.A.
Protein Similarity: 47.5 N.A. N.A. 34.4 N.A. N.A.
P-Site Identity: 6.6 N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: 26.6 N.A. N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 9 17 9 9 9 9 0 17 17 0 9 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 50 50 9 9 9 17 0 9 9 0 0 % D
% Glu: 0 9 0 0 9 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 9 0 0 0 0 0 9 9 0 0 50 0 0 0 0 % F
% Gly: 9 0 9 50 9 17 9 0 0 0 9 0 0 0 25 % G
% His: 0 0 0 9 9 0 0 0 0 0 0 50 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 9 0 0 0 50 9 0 % I
% Lys: 50 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 9 0 0 9 9 9 9 9 0 0 9 9 0 0 % L
% Met: 0 0 9 0 0 0 0 0 9 0 0 0 9 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 50 0 0 0 9 0 0 % N
% Pro: 0 59 0 0 0 0 0 0 9 0 9 9 0 9 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 50 0 9 0 0 0 % Q
% Arg: 9 0 9 0 0 9 50 9 0 0 0 9 0 59 50 % R
% Ser: 0 0 59 0 0 0 0 0 0 0 0 0 0 0 9 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % T
% Val: 9 9 0 9 0 0 0 0 0 9 9 0 0 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % W
% Tyr: 0 9 0 0 0 0 0 50 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _