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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HYPK All Species: 9.09
Human Site: S158 Identified Species: 15.38
UniProt: Q9NX55 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.38
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NX55 NP_057484.3 175 19332 S158 S R A A A E R S L R E H M G N
Chimpanzee Pan troglodytes XP_001160408 175 19359 S158 S R A A A E R S L R E H M G N
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_544652 165 18079 S148 S R A A A E R S L R E H M G N
Cat Felis silvestris
Mouse Mus musculus Q9CR41 129 14661 R114 A A A E R S L R E H M G N V V
Rat Rattus norvegicus XP_230510 151 17054 R136 A A A E R S L R E H M G N V V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001233640 74 8234 R59 A A A E R S L R E H M G N V V
Frog Xenopus laevis Q6IP73 213 23187 A196 S R A K A V R A L K N N S N D
Zebra Danio Brachydanio rerio Q8JIU7 215 23381 A198 S R A K A V R A L K N N N N D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650329 124 14003 E109 H A E K V L R E Q S G D V V A
Honey Bee Apis mellifera XP_624932 147 16724 R132 N V A E Q T L R E H R G N V V
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785775 113 12400 L97 R S E A E R S L R E N K G D P
Poplar Tree Populus trichocarpa XP_002311382 111 12171 R96 K V A E R T L R E H K G D A V
Maize Zea mays NP_001148118 117 12494 R102 K I A E R T L R E H K G D A V
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q94JX9 217 23694 A200 S R S K A V K A L K S H D G D
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 N.A. 77.1 N.A. 73.1 77.1 N.A. N.A. 35.4 21.6 22.3 N.A. 37.7 45.7 N.A. 36.5
Protein Similarity: 100 99.4 N.A. 79.4 N.A. 73.7 80 N.A. N.A. 36 41.3 40.4 N.A. 55.4 60 N.A. 48.5
P-Site Identity: 100 100 N.A. 100 N.A. 6.6 6.6 N.A. N.A. 6.6 40 40 N.A. 6.6 6.6 N.A. 6.6
P-Site Similarity: 100 100 N.A. 100 N.A. 13.3 13.3 N.A. N.A. 13.3 66.6 66.6 N.A. 13.3 13.3 N.A. 6.6
Percent
Protein Identity: 24.5 29.7 N.A. 22.5 N.A. N.A.
Protein Similarity: 42.8 47.4 N.A. 38.7 N.A. N.A.
P-Site Identity: 6.6 6.6 N.A. 40 N.A. N.A.
P-Site Similarity: 13.3 13.3 N.A. 73.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 22 29 79 29 43 0 0 22 0 0 0 0 0 15 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 8 22 8 22 % D
% Glu: 0 0 15 43 8 22 0 8 43 8 22 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 8 43 8 29 0 % G
% His: 8 0 0 0 0 0 0 0 0 43 0 29 0 0 0 % H
% Ile: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 15 0 0 29 0 0 8 0 0 22 15 8 0 0 0 % K
% Leu: 0 0 0 0 0 8 43 8 43 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 22 0 22 0 0 % M
% Asn: 8 0 0 0 0 0 0 0 0 0 22 15 36 15 22 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % P
% Gln: 0 0 0 0 8 0 0 0 8 0 0 0 0 0 0 % Q
% Arg: 8 43 0 0 36 8 43 43 8 22 8 0 0 0 0 % R
% Ser: 43 8 8 0 0 22 8 22 0 8 8 0 8 0 0 % S
% Thr: 0 0 0 0 0 22 0 0 0 0 0 0 0 0 0 % T
% Val: 0 15 0 0 8 22 0 0 0 0 0 0 8 36 43 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _