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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT5
All Species:
9.09
Human Site:
S198
Identified Species:
18.18
UniProt:
Q9NXA8
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.55
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NXA8
NP_036373.1
310
33881
S198
E
P
G
T
Q
D
A
S
I
P
V
E
K
L
P
Chimpanzee
Pan troglodytes
XP_001169349
310
33894
S198
E
P
G
T
Q
D
A
S
I
P
I
E
K
L
P
Rhesus Macaque
Macaca mulatta
XP_001091987
310
33862
S198
E
P
G
T
Q
D
A
S
I
P
V
E
K
L
P
Dog
Lupus familis
XP_535891
310
33924
R198
D
P
E
A
Q
D
A
R
I
P
V
E
K
L
P
Cat
Felis silvestris
Mouse
Mus musculus
Q8K2C6
310
34116
R198
E
P
E
T
Q
D
A
R
I
P
V
D
K
L
P
Rat
Rattus norvegicus
Q68FX9
310
34080
R198
E
P
D
T
Q
E
S
R
I
P
V
H
K
L
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514986
396
42939
R284
E
P
E
I
Q
D
A
R
I
P
I
E
N
L
P
Chicken
Gallus gallus
XP_418925
423
45358
A311
D
P
E
I
E
D
A
A
I
P
V
E
E
L
P
Frog
Xenopus laevis
NP_001088966
309
34085
K197
E
S
D
V
Q
D
A
K
I
P
V
E
Q
L
P
Zebra Danio
Brachydanio rerio
NP_001002605
305
33910
R194
D
P
N
T
K
E
A
R
I
P
V
E
L
L
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_625080
265
29423
Q196
L
D
D
Y
I
M
Q
Q
A
H
I
A
V
E
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780446
226
25512
G158
S
P
I
V
L
A
L
G
D
R
G
E
P
D
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
98
87
N.A.
86.1
85.4
N.A.
66.1
58.3
76.4
69.3
N.A.
N.A.
50.9
N.A.
44.1
Protein Similarity:
100
98.7
98.7
90.6
N.A.
90
90
N.A.
70.4
64.5
83.2
78.3
N.A.
N.A.
66.7
N.A.
54.1
P-Site Identity:
100
93.3
100
73.3
N.A.
80
66.6
N.A.
66.6
60
66.6
60
N.A.
N.A.
0
N.A.
13.3
P-Site Similarity:
100
100
100
80
N.A.
86.6
80
N.A.
73.3
86.6
73.3
80
N.A.
N.A.
6.6
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
9
0
9
75
9
9
0
0
9
0
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
25
9
25
0
0
67
0
0
9
0
0
9
0
9
0
% D
% Glu:
59
0
34
0
9
17
0
0
0
0
0
75
9
9
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
25
0
0
0
0
9
0
0
9
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
9
0
9
0
0
0
% H
% Ile:
0
0
9
17
9
0
0
0
84
0
25
0
0
0
0
% I
% Lys:
0
0
0
0
9
0
0
9
0
0
0
0
50
0
0
% K
% Leu:
9
0
0
0
9
0
9
0
0
0
0
0
9
84
0
% L
% Met:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
9
0
0
0
0
0
0
0
0
0
9
0
9
% N
% Pro:
0
84
0
0
0
0
0
0
0
84
0
0
9
0
84
% P
% Gln:
0
0
0
0
67
0
9
9
0
0
0
0
9
0
0
% Q
% Arg:
0
0
0
0
0
0
0
42
0
9
0
0
0
0
0
% R
% Ser:
9
9
0
0
0
0
9
25
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
50
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
17
0
0
0
0
0
0
67
0
9
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _