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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT5
All Species:
23.94
Human Site:
S24
Identified Species:
47.88
UniProt:
Q9NXA8
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NXA8
NP_036373.1
310
33881
S24
C
G
L
K
P
P
A
S
T
R
N
Q
I
C
L
Chimpanzee
Pan troglodytes
XP_001169349
310
33894
S24
C
G
L
K
P
P
A
S
T
R
N
Q
I
C
P
Rhesus Macaque
Macaca mulatta
XP_001091987
310
33862
S24
C
G
L
K
P
P
A
S
T
R
N
Q
I
C
L
Dog
Lupus familis
XP_535891
310
33924
S24
R
G
L
K
S
P
A
S
T
G
T
R
I
C
P
Cat
Felis silvestris
Mouse
Mus musculus
Q8K2C6
310
34116
S24
C
R
R
K
P
P
A
S
P
Q
S
K
I
C
L
Rat
Rattus norvegicus
Q68FX9
310
34080
S24
C
G
P
K
P
S
A
S
P
Q
S
K
I
C
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514986
396
42939
S110
G
E
L
K
L
P
A
S
K
R
L
K
I
C
I
Chicken
Gallus gallus
XP_418925
423
45358
P137
H
G
A
L
K
P
A
P
K
K
P
N
W
C
W
Frog
Xenopus laevis
NP_001088966
309
34085
S23
Y
C
G
L
K
P
A
S
Q
K
K
S
I
A
L
Zebra Danio
Brachydanio rerio
NP_001002605
305
33910
N23
L
C
A
A
V
R
L
N
W
R
S
P
K
M
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_625080
265
29423
G24
V
L
I
L
T
G
S
G
I
S
A
E
S
G
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780446
226
25512
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
98
87
N.A.
86.1
85.4
N.A.
66.1
58.3
76.4
69.3
N.A.
N.A.
50.9
N.A.
44.1
Protein Similarity:
100
98.7
98.7
90.6
N.A.
90
90
N.A.
70.4
64.5
83.2
78.3
N.A.
N.A.
66.7
N.A.
54.1
P-Site Identity:
100
93.3
100
60
N.A.
60
60
N.A.
53.3
26.6
33.3
6.6
N.A.
N.A.
0
N.A.
0
P-Site Similarity:
100
93.3
100
66.6
N.A.
80
80
N.A.
66.6
33.3
40
20
N.A.
N.A.
26.6
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
17
9
0
0
75
0
0
0
9
0
0
9
0
% A
% Cys:
42
17
0
0
0
0
0
0
0
0
0
0
0
67
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
9
0
0
0
0
0
0
0
0
0
9
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
9
50
9
0
0
9
0
9
0
9
0
0
0
9
0
% G
% His:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
9
0
0
0
0
0
9
0
0
0
67
0
17
% I
% Lys:
0
0
0
59
17
0
0
0
17
17
9
25
9
0
0
% K
% Leu:
9
9
42
25
9
0
9
0
0
0
9
0
0
0
42
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% M
% Asn:
0
0
0
0
0
0
0
9
0
0
25
9
0
0
0
% N
% Pro:
0
0
9
0
42
67
0
9
17
0
9
9
0
0
17
% P
% Gln:
0
0
0
0
0
0
0
0
9
17
0
25
0
0
0
% Q
% Arg:
9
9
9
0
0
9
0
0
0
42
0
9
0
0
0
% R
% Ser:
0
0
0
0
9
9
9
67
0
9
25
9
9
0
0
% S
% Thr:
0
0
0
0
9
0
0
0
34
0
9
0
0
0
9
% T
% Val:
9
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
9
0
0
0
9
0
9
% W
% Tyr:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _